Jacquelyn R Evans, Jennifer M Ladd, Miriam R Conces, Scott E Hickey, Daniel C Koboldt, Y Frances Fei
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引用次数: 0
Abstract
Background: Up to 10-12% of individuals with Turner Syndrome (TS) have Y chromosome material (e.g. 45,X/46,XY), which can lead to virilization. We present the case of a patient with TS who developed virilization due to ovarian hilus cell (OHC) hyperplasia.
Clinical case: An 11-year-old with TS presented with clitoromegaly, hyperandrogenism, and primary ovarian insufficiency (POI). Thorough work up was unable to identify the source of hyperandrogenism. She underwent laparoscopic bilateral gonadectomy and was diagnosed with OHC hyperplasia on pathologic evaluation. Hyperandrogenism resolved post-operatively.
Conclusion: OHC hyperplasia is a rare, but important diagnosis to consider. Laparoscopic bilateral gonadectomy is both diagnostic and therapeutic and should be considered a first-line treatment for patients with POI and virilization in the absence of other diagnosed etiology.
期刊介绍：
Journal of Pediatric and Adolescent Gynecology includes all aspects of clinical and basic science research in pediatric and adolescent gynecology. The Journal draws on expertise from a variety of disciplines including pediatrics, obstetrics and gynecology, reproduction and gynecology, reproductive and pediatric endocrinology, genetics, and molecular biology.
The Journal of Pediatric and Adolescent Gynecology features original studies, review articles, book and literature reviews, letters to the editor, and communications in brief. It is an essential resource for the libraries of OB/GYN specialists, as well as pediatricians and primary care physicians.
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