Prognostic nutritional index as a biomarker for identifying coronary artery lesions in Kawasaki disease

IF 3 4区医学 Q1 PEDIATRICS

Jornal de pediatria Pub Date : 2025-09-01 Epub Date: 2025-08-18 DOI:10.1016/j.jped.2025.101436

Chao Zhang , Guoshun Mao , Guosheng Hu

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引用次数: 0

Abstract

Objective

To evaluate the Prognostic Nutritional Index as a biomarker for identifying coronary artery lesions in Kawasaki disease.

Methods

The clinicopathological and laboratory characteristics of 241 patients with Kawasaki disease were collected from patients who were hospitalized in Fuyang People's Hospital from January 2018 to December 2024. Logistic regression analysis was conducted to evaluate the relationship between Prognostic Nutritional Index and coronary artery lesions. The critical levels of hematological parameters were determined by receiver operating characteristic analysis.

Results

The incidence of coronary artery lesions was 10.3 %. The optimal cut-off point for the Prognostic Nutritional Index was defined as 46.575. Prognostic Nutritional Index was negatively correlated with coronary artery diameter (r = −0.260, p < 0.001). Patients with low Prognostic Nutritional Index levels (Prognostic Nutritional Index < 46.575) were 4.25 times more likely to have coronary artery lesions compared to those with high Prognostic Nutritional Index levels (Prognostic Nutritional Index ≥ 46.575) (OR = 4.25, 95 % CI: 1.688 - 10.697, p < 0.001). The area under the receiver operating characteristic curve for Prognostic Nutritional Index in predicting coronary artery lesions was 0.702 (95 % CI: 0.584 - 0.821, p = 0.001), indicating moderate diagnostic efficacy.

Conclusion

Prognostic Nutritional Index may be a biomarker for children with Kawasaki disease complicated with coronary artery lesions, and it may help identify high-risk patients of coronary artery lesions among children with Kawasaki disease.

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预后营养指数作为鉴别川崎病冠状动脉病变的生物标志物。

目的：评价预后营养指数作为鉴别川崎病冠状动脉病变的生物标志物。方法：收集2018年1月至2024年12月阜阳市人民医院住院的241例川崎病患者的临床病理和实验室特征。采用Logistic回归分析评价预后营养指数与冠状动脉病变的关系。通过受试者工作特征分析确定血液学参数的临界水平。结果：冠状动脉病变发生率为10.3 %。预后营养指数的最佳分界点为46.575。预后营养指数与冠状动脉直径呈负相关（r = -0.260,p ）结论：预后营养指数可能是川崎病患儿合并冠状动脉病变的生物标志物，有助于川崎病患儿中冠状动脉病变高危患者的识别。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Jornal de pediatria 医学-小儿科

CiteScore

5.60

自引率

3.00%

发文量

审稿时长

43 days

期刊介绍： Jornal de Pediatria is a bimonthly publication of the Brazilian Society of Pediatrics (Sociedade Brasileira de Pediatria, SBP). It has been published without interruption since 1934. Jornal de Pediatria publishes original articles and review articles covering various areas in the field of pediatrics. By publishing relevant scientific contributions, Jornal de Pediatria aims at improving the standards of pediatrics and of the healthcare provided for children and adolescents in general, as well to foster debate about health.