Motor Neuron Loss Detection Based on EMG Probability Density Function Shape Descriptors

IF 5.2 2区 医学 Q2 ENGINEERING, BIOMEDICAL
Javier Navallas;Lucia Biurrun;Cristina Mariscal;Silvia Recalde-Villamayor;Armando Malanda;Javier Rodríguez-Falces
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Abstract

EMG interference pattern analysis is routinely used in the assessment of motor neuron loss. We propose systematizing interference pattern analysis by recording an isometric ramp contraction of a muscle, from minimum to maximum activation level. Three EMG probability density function (PDF) shape descriptors are then employed to quantify the PDF evolution assessing EMG filling through contraction: filling factor, negentropy, and kurtosis. The three filling curves are fitted with an exponential model, and the decay constant parameters are employed to obtain a feature vector that characterizes the EMG filling behavior of the muscle. Results show a tendency of the filling curves to shorten and not reach saturation when neuropathy is simulated, and a subsequent dependency of the decay constant parameters with neuropathy progression. We demonstrate, with a set of real signals and through simulation experiments, the ability of the features to be used by a classification system to detect motor neuron loss. With the set of real signals (from 40 subjects with L5 radiculopathy and 40 healthy controls), results show a 0.86 sensibility and 0.84 specificity, indicating a promising performance when incorporated into clinical decision support systems.
基于EMG概率密度函数形状描述符的运动神经元损失检测。
肌电图干扰模式分析通常用于评估运动神经元的损失。我们建议通过记录肌肉从最小到最大激活水平的等距斜坡收缩来系统化干扰模式分析。然后采用填充因子、负熵和峰度三个肌电概率密度函数(PDF)形状描述符来量化通过收缩评估肌电填充的PDF演化。用指数模型拟合三条填充曲线,利用衰减常数参数得到表征肌电填充行为的特征向量。结果显示,当模拟神经病变时,填充曲线有缩短且未达到饱和的趋势,并且衰减常数参数随后与神经病变进展相关。通过一组真实信号和模拟实验,我们证明了分类系统使用这些特征来检测运动神经元损失的能力。使用一组真实信号(来自40名L5神经根病患者和40名健康对照者),结果显示敏感性为0.86,特异性为0.84,表明将其纳入临床决策支持系统具有良好的性能。
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来源期刊
CiteScore
8.60
自引率
8.20%
发文量
479
审稿时长
6-12 weeks
期刊介绍: Rehabilitative and neural aspects of biomedical engineering, including functional electrical stimulation, acoustic dynamics, human performance measurement and analysis, nerve stimulation, electromyography, motor control and stimulation; and hardware and software applications for rehabilitation engineering and assistive devices.
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