Behçet's Disease In Children And Adults Of Sub-Saharan Ancestry: A Systematic Review And Meta-Analysis.

IF 11.3 2区医学 Q1 ALLERGY

Clinical Reviews in Allergy & Immunology Pub Date : 2025-08-14 DOI:10.1007/s12016-025-09085-8

Benoit Suzon, Arthur Felix, Fabienne Louis-Sidney, Esther Dalmasie, Sunniva Donat, Christophe Deligny, Aurore Abel, Eleonore de Fritsch

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引用次数: 0

Abstract

Background: The characteristics of Behçet's disease (BD) in individuals of Sub-Saharan ancestry (sub-SA) are poorly understood.

Methods: Herein, we conducted a PRISMA-compliant systematic review using the PubMed/Medline, Scopus, and Web of Science databases. Articles published up to September 1, 2023 were searched with the following keywords: "Behçet's disease" OR "Behcet's syndrome" AND "sub-Saharan African" OR "Black" OR "African". Data on the year, type and country of study, sample size, region of origin, nationality, age, sex, time to diagnosis, death, HLAB51 status, mucosal, and organ involvement were collected. Involvement of the central nervous system was retained on the basis of objective criteria, and dichotomized into parenchymal or non-parenchymal/vascular lesions. The pooled frequency of patients' main characteristics was calculated using a DerSimonian-Laird random-effects meta-analysis.

Results: This study included 42 full-text reports, with study periods ranging from 1970 to 2023. Overall, 230 adult patients (69% of males) were included, of whom 195 (85%) were from sub-Saharan African countries, 22 (10%) patients were from the Caribbean, and 13 (5%) patients were from the Americas, including 12 African Americans, and 1 African Brazilian. Oral and genital ulcers were reported in 98% [95% CI 91 to 100%] and 85% [72 to 92%], respectively. Ocular involvement occurred in 43% [31 to 56%] of patients. Central nervous system (CNS) involvement affected 39% [25 to 54] of the patients. Among them, 30% of patients had a cerebro-vascular disease, and 72% had a parenchymal involvement. The patients were mostly treated with oral steroids and colchicine, and remission was achieved in 35/54 (65%) patients, but 15 (69%) of them suffered severe sequelae, particularly ophthalmological and neurological.

Conclusion: Behçet's disease in patients of sub-Saharan ancestry appears to be predominantly HLA B51/B5-negative, and more severe than in other ethnicities, owing to a high prevalence of CNS involvement.

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撒哈拉以南地区儿童和成人behaperet病：系统回顾和荟萃分析

背景：撒哈拉以南血统（sub-SA）个体behaperet病（BD）的特征尚不清楚。方法：在此，我们使用PubMed/Medline、Scopus和Web of Science数据库进行了符合prisma标准的系统评价。在2023年9月1日之前发表的文章中，使用以下关键词进行搜索：“贝切特病”或“贝切特综合征”和“撒哈拉以南非洲”或“黑人”或“非洲人”。收集有关年份、研究类型和国家、样本量、原产地区、国籍、年龄、性别、诊断时间、死亡、HLAB51状态、粘膜和器官受累的数据。根据客观标准保留中枢神经系统的受累，并将其分为实质性或非实质性/血管性病变。使用dersimonan - laird随机效应荟萃分析计算患者主要特征的合并频率。结果：本研究包括42份全文报告，研究时间从1970年到2023年。总共纳入230名成年患者（69%为男性），其中195名（85%）来自撒哈拉以南非洲国家，22名（10%）患者来自加勒比地区，13名（5%）患者来自美洲，包括12名非洲裔美国人和1名非洲裔巴西人。口腔溃疡和生殖器溃疡的发生率分别为98% [95% CI 91 ~ 100%]和85%[72 ~ 92%]。43%[31 ~ 56%]的患者发生眼部受累。中枢神经系统（CNS）受累的患者占39%[25 ~ 54]。其中30%的患者有脑血管疾病，72%的患者有实质受累。患者大多采用口服类固醇和秋水仙碱治疗，35/54（65%）患者缓解，但15（69%）患者有严重的后遗症，特别是眼科和神经系统。结论：由于中枢神经系统的高患病率，撒哈拉以南血统患者的behet病似乎主要是HLA B51/ b5阴性，并且比其他种族更严重。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Reviews in Allergy & Immunology 医学-过敏

CiteScore

22.30

自引率

1.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.