Research progress on the mechanisms of CSF3R mutations in leukemogenesis and treatment strategies.

IF 6 2区医学 Q1 ONCOLOGY

Cancer Cell International Pub Date : 2025-08-14 DOI:10.1186/s12935-025-03941-5

Ningxuan Wang, Xiangan Li, Chenyang She, Jun Zhang

引用次数: 0

Abstract

Leukemia is a malignant clonal disease originating from hematopoietic stem cells. Its pathogenesis is associated with multiple factors, including biological, physical, chemical, genetic, and other hematological diseases. Previous studies have shown that a high mutation rate (>80%) of colony-stimulating factor receptor 3 (CSF3R) is observed in chronic neutrophilic leukemia (CNL) patients, and these mutations activate downstream signaling pathways, leading to the proliferation of neutrophils. In-depth research on the CSF3R genes and their related mechanisms will help further reveal the mechanisms of leukemia development and provide potential targets for treatment. Therefore, this paper mainly focuses on the roles of colony-stimulating factor 3 (CSF3R) in hematopoiesis and the occurrence of leukemia, with particular attention to the roles of CSF3R in the JAK-STAT, PI3K-AKT, and MAPK-ERK signaling pathways.

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CSF3R突变在白血病发生中的机制及治疗策略的研究进展。

白血病是一种起源于造血干细胞的恶性克隆性疾病。其发病机制与多种因素有关，包括生物、物理、化学、遗传等血液病。既往研究表明，在慢性中性粒细胞白血病（CNL）患者中观察到集落刺激因子受体3 （CSF3R）的高突变率（bbb80 %），这些突变激活下游信号通路，导致中性粒细胞增殖。对CSF3R基因及其相关机制的深入研究，将有助于进一步揭示白血病的发生机制，提供潜在的治疗靶点。因此，本文主要关注集落刺激因子3 （colony-stimulating factor 3, CSF3R）在造血和白血病发生中的作用，尤其关注CSF3R在JAK-STAT、PI3K-AKT和MAPK-ERK信号通路中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell International ONCOLOGY-

CiteScore

10.90

自引率

1.70%

发文量

360

审稿时长

1 months

期刊介绍： Cancer Cell International publishes articles on all aspects of cancer cell biology, originating largely from, but not limited to, work using cell culture techniques. The journal focuses on novel cancer studies reporting data from biological experiments performed on cells grown in vitro, in two- or three-dimensional systems, and/or in vivo (animal experiments). These types of experiments have provided crucial data in many fields, from cell proliferation and transformation, to epithelial-mesenchymal interaction, to apoptosis, and host immune response to tumors. Cancer Cell International also considers articles that focus on novel technologies or novel pathways in molecular analysis and on epidemiological studies that may affect patient care, as well as articles reporting translational cancer research studies where in vitro discoveries are bridged to the clinic. As such, the journal is interested in laboratory and animal studies reporting on novel biomarkers of tumor progression and response to therapy and on their applicability to human cancers.