Assessment of Small Nerve Fibers Using the Cutaneous Silent Period: Effect of Age and Gender.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Annals of Indian Academy of Neurology Pub Date : 2025-08-14 DOI:10.4103/aian.aian_165_25

Sarah M Kaddah, Lamia Afifi, Heba Raafat, Alshaimaa Sobhi Khalil

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引用次数: 0

Abstract

Background and objectives: Small fiber neuropathy cannot be detected using conventional nerve conduction studies. The use of the cutaneous silent period (CSP) could represent an effective non-invasive test in evaluating the small nerve fibers. The current work aimed to evaluate the CSP among healthy individuals across different decades and assess the effect of gender on CSP values.

Methods: 71 healthy volunteers with an age range of 20-60 years were included in this study. Several CSP parameters were measured, including CSP latencies and duration of the median, ulnar, and sural nerves.

Results: We obtained the mean CSP parameters for the mentioned upper and lower limb nerves across different decades. Age had a significant impact on CSP latencies. Males showed longer latencies than females. No significant inter-side CSP difference was noted.

Conclusion: The CSP test is a non-invasive tolerable test and could serve as an important addition to routine electrophysiological examination. The age and gender significantly impact the CSP latency. The establishment of normative data and an understanding of the effects of age and gender is essential for proper employment.

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使用皮肤沉默期评估小神经纤维：年龄和性别的影响。

背景和目的：小纤维神经病变不能通过传统的神经传导检查检测到。使用皮肤沉默期（CSP）可以作为一种有效的非侵入性测试来评估小神经纤维。本研究旨在评估不同年龄健康个体的CSP，并评估性别对CSP值的影响。方法：选取年龄在20 ~ 60岁的健康志愿者71例。测量了几个CSP参数，包括CSP潜伏期和正中神经、尺神经和腓肠神经的持续时间。结果：我们得到了不同年代上肢和下肢神经的平均CSP参数。年龄对CSP潜伏期有显著影响。雄性的潜伏期比雌性长。两侧CSP无显著差异。结论：CSP试验是一种无创的耐受性试验，可作为常规电生理检查的重要补充。年龄和性别对CSP潜伏期有显著影响。建立规范性数据和了解年龄和性别的影响对适当就业至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Indian Academy of Neurology Nervous System Diseases-

CiteScore

2.20

自引率

11.80%

发文量

293

审稿时长

29 weeks

期刊介绍： The journal has a clinical foundation and has been utilized most by clinical neurologists for improving the practice of neurology. While the focus is on neurology in India, the journal publishes manuscripts of high value from all parts of the world. Journal publishes reviews of various types, original articles, short communications, interesting images and case reports. The journal respects the scientific submission of its authors and believes in following an expeditious double-blind peer review process and endeavors to complete the review process within scheduled time frame. A significant effort from the author and the journal perhaps enables to strike an equilibrium to meet the professional expectations of the peers in the world of scientific publication. AIAN believes in safeguarding the privacy rights of human subjects. In order to comply with it, the journal instructs all authors when uploading the manuscript to also add the ethical clearance (human/animals)/ informed consent of subject in the manuscript. This applies to the study/case report that involves animal/human subjects/human specimens e.g. extracted tooth part/soft tissue for biopsy/in vitro analysis.