Gary W. Liu*, Ruitao Su, Bianca Lorraine Garcia Osterling, Ruben Carrazco and Vivian R. Feig*,
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引用次数: 0
Abstract
Ingestible hydrogels have long been used in food and therapeutic applications. Their polymeric composition endows these materials with programmable and dynamic properties to operate within the complex gastrointestinal tract. Recent advances have pushed the boundaries of hydrogel behavior and function; incorporating these features may enable new strategies to manage gastrointestinal and systemic diseases. In this perspective, we highlight some commercial ingestible hydrogel products to establish their current capabilities. We then discuss some recent advances of ingestible hydrogels that push these capabilities in the areas of tissue-specific activity, ultralong retention within the gastrointestinal tract, and incorporation into ingestible electronics and robots. Finally, we discuss some key considerations for translating ingestible macroscale hydrogels, which requires early consideration of in vivo models and regulation, safety, and manufacturing.
期刊介绍：
Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine.
Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.
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