Electrochemical Study of a WO₃ NPs/MoO₃ Heterojunction-Based Dual-Enzyme Amperometric Acetylcholine Sensor

IF 4.3 2区综合性期刊 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

IEEE Sensors Journal Pub Date : 2025-07-10 DOI:10.1109/JSEN.2025.3585203

Chih-Hsien Lai;Yu-Wei Chen;Jung-Chuan Chou;Po-Hui Yang;Po-Yu Kuo;Yu-Hsun Nien;Xin-Han Chen

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引用次数: 0

Abstract

This study proposes an acetylcholine (ACh) sensor based on a molybdenum trioxide (MoO3) film modified with tungsten trioxide (WO3) nanoparticles (NPs). The MoO3 film was first prepared by radio frequency (RF) sputtering, followed by drop-casting of hydrothermally synthesized WO3 NPs for hydrogen ion detection. X-ray diffraction (XRD), together with transmission electron microscopy (TEM) and selected-area electron diffraction, confirmed the crystal phase of WO3 NPs, while energy-dispersive X-ray spectroscopy (EDX) verified the homogeneous elemental distribution. In addition, ultraviolet photoelectron spectroscopy (UPS), low-energy inverse photoelectron spectroscopy (LEIPS), and ultraviolet-visible spectroscopy were used to confirm the band structure, and X-ray photoelectron spectroscopy (XPS) further verified successful material synthesis. Electrochemical impedance spectroscopy (EIS) further revealed that the WO3 NPs/MoO3 configuration enhances charge transport across the liquid interface. This sensor exhibits a high sensitivity (

$31.85~\mu ~\text {A}\cdot \text { decade}~^{-{1}}\cdot \text { cm}^{-{2}}$

), a limit of detection (LOD) (

$1.37\times 10^{-{10}}$

M), and acceptable interference tolerance, offering a novel approach for detecting low concentrations of ACh.

查看原文本刊更多论文

WO₃NPs/MoO₃异质结双酶型乙酰胆碱传感器的电化学研究

本研究提出了一种基于三氧化钨（WO3）纳米粒子修饰的三氧化钼（MoO3）薄膜的乙酰胆碱（ACh）传感器。首先采用射频溅射法制备MoO3薄膜，然后水滴浇铸水热合成的WO3 NPs用于氢离子检测。x射线衍射（XRD）、透射电镜（TEM）和选择区域电子衍射（select -area electron diffraction）证实了WO3 NPs的晶相，能量色散x射线能谱（EDX）证实了WO3 NPs的元素分布均匀。此外，利用紫外光电子能谱（UPS）、低能逆光电子能谱（LEIPS）和紫外可见能谱（uv -可见光能谱）对其能带结构进行了确认，x射线光电子能谱（XPS）进一步验证了材料合成成功。电化学阻抗谱（EIS）进一步揭示了WO3 NPs/MoO3结构增强了液体界面上的电荷输运。该传感器具有高灵敏度（$31.85~\mu ~\text {a}\cdot \text {decade}~^{-{1}}\cdot \text {cm}^{-{2}}$）、检测限（LOD）（$1.37\ × 10^{-{10}}$ M）和可接受的干扰容限，为检测低浓度乙酰胆碱提供了一种新的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IEEE Sensors Journal 工程技术-工程：电子与电气

CiteScore

7.70

自引率

14.00%

发文量

2058

审稿时长

5.2 months

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