Aqueous-mediated synthesis of 2-amino-7-hydroxy-4-aryl-4H-chromene-3-carbonitrile derivatives using triethanolamine: An effective basic organocatalyst

Farzaneh Mohamadpour
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Abstract

A sustainable method for the effective and simple synthesis of derivatives of 2-amino-7-hydroxy-4-aryl-4H-chromene-3-carbonitrile is developed. The process makes use of a domino Knoevenagel-Michael cyclocondensation reaction. The reaction occurs at reflux in an aqueous solution using triethanolamine, a cheap and effective basic organocatalyst. This process makes use of sustainable chemical principles. Reactions go more rapidly, yielding good to exceptional results. It does not separate mixtures using the chromatographic process. This is an easy and inexpensive way. Reaction times range from 40 to 65 min, with an average of 47.81 min, while yields range from 72 % to 93 %, with an average of 85.06 %. It's also important to note that a variety of functional groups that give or remove electrons may be used with this approach, and yet retain a fast reaction rate and good to exceptional yields. The results show that, given very basic and effective reaction conditions, this approach is a fruitful one-pot procedure. The nature of the substituents has no bearing on the reaction. Because it combines multiple steps into a one-pot, it is both convenient and expedient.
三乙醇胺水催化合成2-氨基-7-羟基-4-芳基-4-铬-3-碳腈衍生物:一种有效的碱性有机催化剂
提出了一种可持续、高效、简便的合成2-氨基-7-羟基-4-芳基-4- h -铬-3-碳腈衍生物的方法。该工艺利用了多米诺骨牌Knoevenagel-Michael环缩合反应。该反应在使用三乙醇胺的水溶液中回流进行,三乙醇胺是一种廉价而有效的碱性有机催化剂。这个过程利用了可持续化学原理。反应进行得更快,产生好的或特殊的结果。它不使用色谱法分离混合物。这是一种既简单又便宜的方法。反应时间范围为40 ~ 65 min,平均为47.81 min,产率范围为72 ~ %,平均为85.06 %。同样重要的是要注意,在这种方法中可以使用各种各样的官能团,这些官能团可以给出或移除电子,但仍然保持快速的反应速率和良好的收率。结果表明,在非常基本和有效的反应条件下,这种方法是一种卓有成效的一锅法。取代基的性质与反应无关。因为它将多个步骤合并到一个锅中,所以既方便又方便。
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