Therapeutic potential and pharmaceutical development of multitargeted polyphenolic compound ethyl gallate

Roshni Sharma , Mohammad Adnan Raza , Anjila Firdous , Ajazuddin
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Abstract

Ethyl gallate, a derivative of gallic acid, having significant characteristics including anti-inflammatory, antioxidant & antiviral, positioning it as potential candidate for therapeutic applications across several different illnesses, such as inflammatory condition, cancer, and viral illnesses like influenza, herpes simplex. Preclinical studies have shown that it has the capacity to modulate inflammation and oxidative stress, both of them plays significant roles in a variety of pathological diseases. The versatility of ethyl gallate in addressing a lot of disease pathways demonstrates its promise in integrated therapeutic methods. However, despite promising in vitro and animal model results, its clinical use remains unknown. The lack of human clinical studies leaves a significant vacuum in our findings, particularly of its safety, efficacy, and comprehensive pharmacological mechanisms. Future study is required to close this gap and establish the therapeutic value of ethyl gallate.
多靶点多酚类化合物没食子酸乙酯的治疗潜力及药物开发
没食子酸乙酯,没食子酸的衍生物,具有抗炎、抗氧化等显著特性;抗病毒,将其定位为治疗几种不同疾病的潜在候选者,如炎症、癌症和病毒性疾病,如流感、单纯疱疹。临床前研究表明,它具有调节炎症和氧化应激的能力,这两者在多种病理疾病中都起着重要作用。没食子酸乙酯在解决许多疾病途径方面的多功能性表明其在综合治疗方法中的前景。然而,尽管体外和动物模型的结果很有希望,其临床应用仍然未知。人类临床研究的缺乏给我们的发现留下了一个重要的真空,特别是它的安全性、有效性和全面的药理学机制。未来的研究需要缩小这一差距,并确定没食子酸乙酯的治疗价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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