Occurrence and risk assessment of ochratoxin A in Turkish dried grapes: Insights from a two year monitoring study

IF 2.7 2区农林科学 Q1 ENTOMOLOGY

Journal of Stored Products Research Pub Date : 2025-08-16 DOI:10.1016/j.jspr.2025.102779

Duygu Nur Emir, Eylem Odabas, Bulent Kabak

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Abstract

Ochratoxin A (OTA) contamination in dried grapes remains a significant concern due to its nephrotoxic and carcinogenic properties. In this study, OTA levels were determined in 116 dried grape samples of Turkish origin collected during the 2023 and 2024 harvest seasons. The analysis was performed using a high-performance liquid chromatography with fluorescence detection (HPLC-FLD) method, which was in-house validated for accuracy and precision. OTA was determined in 13.8 % of the samples, with concentrations ranging from 0.283 to 2.82 μg/kg; none exceeded the European Union's maximum level of 10 μg/kg for dried vine fruits. Health risk assessment based on mean and high-percentile dietary exposure scenarios demonstrated that OTA intake remained within tolerable safety thresholds, as margin of exposure (MOE) values consistently exceeded 10,000. These findings indicate a low potential health risk associated with OTA exposure from dried grape consumption among Turkish adults, while also highlighting the importance of ongoing surveillance to ensure consumer safety.

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土耳其干葡萄中赭曲霉毒素A的发生和风险评估：来自两年监测研究的见解

由于其肾毒性和致癌性，干葡萄中的赭曲霉毒素A （OTA）污染仍然是一个值得关注的问题。在本研究中，对2023年和2024年收获季节收集的116个土耳其产干葡萄样本进行了OTA水平测定。采用高效液相色谱-荧光检测（HPLC-FLD）方法进行分析，并对其准确性和精密度进行了内部验证。13.8%的样品中检出乙酸乙酯，浓度范围为0.283 ~ 2.82 μg/kg；没有超过欧盟规定的葡萄干每公斤10微克的最高水平。基于平均和高百分位饮食暴露情景的健康风险评估表明，OTA摄入量仍在可容忍的安全阈值范围内，因为暴露边际（MOE）值始终超过10,000。这些研究结果表明，土耳其成年人因食用干葡萄而暴露于OTA的潜在健康风险较低，同时也强调了持续监测以确保消费者安全的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Stored Products Research 生物-昆虫学

CiteScore

5.70

自引率

18.50%

发文量

112

审稿时长

45 days

期刊介绍： The Journal of Stored Products Research provides an international medium for the publication of both reviews and original results from laboratory and field studies on the preservation and safety of stored products, notably food stocks, covering storage-related problems from the producer through the supply chain to the consumer. Stored products are characterised by having relatively low moisture content and include raw and semi-processed foods, animal feedstuffs, and a range of other durable items, including materials such as clothing or museum artefacts.