Subcutaneous hyalohyphomycosis in a domestic cat caused by Flavodon flavus, an under-recognized fungal pathogen

IF 1.8 3区农林科学 Q1 VETERINARY SCIENCES

Research in veterinary science Pub Date : 2025-08-14 DOI:10.1016/j.rvsc.2025.105859

J.A.B. Grandinetti , A.N. Etchecopaz , J. Maito , M.L. Cuestas , C. Wright

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Abstract

This report describes the first documented case of subcutaneous hyalohyphomycosis caused by Flavodon flavus in a domestic cat. A 3-year-old spayed indoor cat presented with progressive cutaneous nodules on all four limbs. Histopathology revealed a pyogranulomatous inflammatory response with fungal elements, and fungal culture followed by molecular identification confirmed F. flavus as the etiologic agent. The cat tested negative for FIV and FeLV. Initial treatment with oral itraconazole (5 mg/kg/day) resulted in partial improvement. Due to stagnation in clinical response by day 90, oral potassium iodide (5 mg/kg/day) was added. Combined therapy led to complete resolution of lesions by day 135, and treatment was extended for an additional 60 days. No recurrence has been observed to date. This case highlights the emerging role of F. flavus—an environmental basidiomycete previously unrecognized as a feline pathogen—as a potential cause of subcutaneous mycoses in cats. Long-term antifungal treatment and close monitoring are recommended due to the risk of relapse.

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由黄酮引起的家猫皮下透明丝酵母菌病，一种未被识别的真菌病原体

本报告描述了第一例由黄酮类引起的家猫皮下透明丝酵母菌病。一只3岁的绝育室内猫在四肢出现进行性皮肤结节。组织病理学显示脓肉芽肿性炎症反应与真菌成分，真菌培养和分子鉴定证实黄曲霉为病原。这只猫的FIV和FeLV检测呈阴性。最初口服伊曲康唑（5mg /kg/天）可部分改善。由于到第90天临床反应停滞，口服碘化钾（5mg /kg/天）。联合治疗导致病变在第135天完全消退，并延长治疗60天。至今未见复发。这一病例强调了F. flave（一种以前未被认为是猫科病原体的环境担子菌）作为猫皮下真菌病的潜在病因的新作用。由于复发的风险，建议长期抗真菌治疗并密切监测。

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来源期刊

Research in veterinary science 农林科学-兽医学

CiteScore

4.40

自引率

4.20%

发文量

312

审稿时长

75 days

期刊介绍： Research in Veterinary Science is an International multi-disciplinary journal publishing original articles, reviews and short communications of a high scientific and ethical standard in all aspects of veterinary and biomedical research. The primary aim of the journal is to inform veterinary and biomedical scientists of significant advances in veterinary and related research through prompt publication and dissemination. Secondly, the journal aims to provide a general multi-disciplinary forum for discussion and debate of news and issues concerning veterinary science. Thirdly, to promote the dissemination of knowledge to a broader range of professions, globally. High quality papers on all species of animals are considered, particularly those considered to be of high scientific importance and originality, and with interdisciplinary interest. The journal encourages papers providing results that have clear implications for understanding disease pathogenesis and for the development of control measures or treatments, as well as those dealing with a comparative biomedical approach, which represents a substantial improvement to animal and human health. Studies without a robust scientific hypothesis or that are preliminary, or of weak originality, as well as negative results, are not appropriate for the journal. Furthermore, observational approaches, case studies or field reports lacking an advancement in general knowledge do not fall within the scope of the journal.