Advanced hydrogel therapeutics for intervertebral disc degeneration: Engineering structural–functional properties in natural and synthetic biomaterials

IF 5.7 2区医学 Q1 ENGINEERING, BIOMEDICAL

Bioengineering & Translational Medicine Pub Date : 2025-08-11 DOI:10.1002/btm2.70059

Tao Chen, Dading Lu, Siqiao Wang, Huiyi Yang, Wenyong Fan, Zhihui Xiao, Zhaojie Wang, Pooyan Makvandi, Rongrong Zhu, Liming Cheng

{"title":"Advanced hydrogel therapeutics for intervertebral disc degeneration: Engineering structural–functional properties in natural and synthetic biomaterials","authors":"Tao Chen, Dading Lu, Siqiao Wang, Huiyi Yang, Wenyong Fan, Zhihui Xiao, Zhaojie Wang, Pooyan Makvandi, Rongrong Zhu, Liming Cheng","doi":"10.1002/btm2.70059","DOIUrl":null,"url":null,"abstract":"Low back pain is a global health challenge, imposing substantial socioeconomic burdens. Intervertebral disc degeneration (IVDD) is a leading cause of low back pain and can lead to further spinal complications. Current treatments for IVDD are limited to conservative measures and surgery, lacking curative options. Advances in biomaterials science and regenerative medicine have introduced bioactive hydrogels as promising treatments for IVDD. This review summarizes the physiology of the intervertebral disc, the pathophysiology of IVDD, existing diagnostic methods, and current treatment strategies. Importantly, this review examines recent advances in hydrogel treatments for IVDD, emphasizing the biological and material properties of various hydrogels. It compares the advantages and limitations of natural and synthetic hydrogels, outlining the classification of hydrogel delivery substances. Lastly, it identifies current challenges and suggests future research directions to optimize the application of bioactive materials in IVDD treatment.","PeriodicalId":9263,"journal":{"name":"Bioengineering & Translational Medicine","volume":"15 1","pages":""},"PeriodicalIF":5.7000,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioengineering & Translational Medicine","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1002/btm2.70059","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Low back pain is a global health challenge, imposing substantial socioeconomic burdens. Intervertebral disc degeneration (IVDD) is a leading cause of low back pain and can lead to further spinal complications. Current treatments for IVDD are limited to conservative measures and surgery, lacking curative options. Advances in biomaterials science and regenerative medicine have introduced bioactive hydrogels as promising treatments for IVDD. This review summarizes the physiology of the intervertebral disc, the pathophysiology of IVDD, existing diagnostic methods, and current treatment strategies. Importantly, this review examines recent advances in hydrogel treatments for IVDD, emphasizing the biological and material properties of various hydrogels. It compares the advantages and limitations of natural and synthetic hydrogels, outlining the classification of hydrogel delivery substances. Lastly, it identifies current challenges and suggests future research directions to optimize the application of bioactive materials in IVDD treatment.

查看原文本刊更多论文

先进的水凝胶治疗椎间盘退变：天然和合成生物材料的工程结构功能特性

腰痛是一个全球性的健康挑战，造成了巨大的社会经济负担。椎间盘退变（IVDD）是腰痛的主要原因，并可导致进一步的脊柱并发症。目前IVDD的治疗仅限于保守措施和手术，缺乏治愈的选择。生物材料科学和再生医学的进步已经引入了生物活性水凝胶作为IVDD的有希望的治疗方法。本文综述了椎间盘的生理学、IVDD的病理生理学、现有的诊断方法和目前的治疗策略。重要的是，本文综述了水凝胶治疗IVDD的最新进展，强调了各种水凝胶的生物学和材料特性。比较了天然水凝胶和合成水凝胶的优点和局限性，概述了水凝胶输送物质的分类。最后，提出了优化生物活性材料在IVDD治疗中的应用所面临的挑战和未来的研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Bioengineering & Translational Medicine Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

8.40

自引率

4.10%

发文量

150

审稿时长

12 weeks

期刊介绍： Bioengineering & Translational Medicine, an official, peer-reviewed online open-access journal of the American Institute of Chemical Engineers (AIChE) and the Society for Biological Engineering (SBE), focuses on how chemical and biological engineering approaches drive innovative technologies and solutions that impact clinical practice and commercial healthcare products.