Coherent-Excitation PACT With Frequency-Compensated Reconstruction for High-Contrast Deep-Tissue Imaging.

IF 2.3
Ruijie Hou, Jun Ye, Yang Zhang, Feng Hua, Bin Xu, Xuefeng Liu, Muhammad Qasim Mehmood, Jichuan Xiong
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Abstract

Photoacoustic computed tomography (PACT) synergizes optical absorption contrast with ultrasonic resolution for noninvasive biomedical imaging yet faces limitations in signal-to-noise ratio (SNR), resolution, and contrast. This study introduces a coherent-excitation PACT system integrating interferometric optical excitation and Frequency-Compensated Filtered Back Projection (FC-FBP) reconstruction. The proposed method utilizes phase-locked dual-pulse interferometric excitation to amplify photoacoustic emissions; for the isolated chicken heart, the resolution is improved by 7.9% compared to the single-pulse protocol. The FC-FBP algorithm compensates for frequency-dependent acoustic attenuation via depth-adaptive Gaussian filtering, enhancing the projected signal in the target area while suppressing speckle artifacts. Through experimental validation, we confirm that the coherent-excitation scheme enables simultaneous optimization of optical fluence distribution and acoustic coherence; hence, it can be used to resolve previously indistinguishable hemoglobin oxygenation gradients in murine tumor models. This advancement establishes a high-sensitivity PACT framework, showing potential for real-time intraoperative imaging and dynamic metabolic monitoring in clinical applications.

基于频率补偿重建的相干激发PACT用于高对比度深部组织成像。
光声计算机断层扫描(PACT)将光学吸收对比度与超声分辨率协同用于无创生物医学成像,但在信噪比(SNR)、分辨率和对比度方面存在局限性。介绍了一种集干涉光激发和频率补偿滤波后投影(FC-FBP)重建于一体的相干激发PACT系统。该方法利用锁相双脉冲干涉激励放大光声发射;对于分离的鸡心脏,与单脉冲方案相比,分辨率提高了7.9%。FC-FBP算法通过深度自适应高斯滤波补偿频率相关的声衰减,增强目标区域的投影信号,同时抑制散斑伪影。通过实验验证,我们证实了相干激励方案可以同时优化光通量分布和声相干性;因此,它可用于解决以前难以区分的小鼠肿瘤模型中的血红蛋白氧化梯度。这一进展建立了一个高灵敏度的PACT框架,显示了在临床应用中实时术中成像和动态代谢监测的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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