Pediatric Graves' disease: insights into clinical characteristics and treatment outcomes.

IF 2.3 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Archives of Endocrinology Metabolism Pub Date : 2025-08-13 DOI:10.20945/2359-4292-2025-0017

Akshatha Anand, Vani Hebbal Nagarajappa, Raghupathy Palany

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Abstract

Objective: To identify early manifestations of Graves' disease in young patients and its treatment outcomes.

Subjects and methods: This was a hospital-based review of case records of 47 children (aged 1 month to 18 years) with Graves' disease from 2011 to 2022. Data were summarized and statistically analyzed.

Results: This study included 47 patients with Graves' disease, of whom 31 (66%) were girls. The average age at the initial diagnosis was 12.79 ± 3.75 years. Common presenting complaints included heat intolerance (76.6%), excessive sweating (74.5%), palpitations (68.1%), tremors (48.9%), weight loss (38.3%), increased appetite (34%), diarrhea (31.9%), and constipation (4.3%). The mean thyrotropin receptor antibody titer was 16.93 ± 13.47 IU/L. Remission was achieved in two (4.3%) patients treated with antithyroid drugs.

Conclusion: Graves' disease is the most common cause of juvenile hyperthyroidism, and treating physicians should be aware of its signs and symptoms to avoid treatment delays.

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儿童格雷夫斯病：临床特征和治疗结果的见解

目的：探讨年轻Graves病患者的早期表现及治疗效果。研究对象和方法：本研究以医院为基础，回顾了2011年至2022年47例Graves病患儿（1个月至18岁）的病例记录。对资料进行汇总和统计分析。结果：本研究纳入47例Graves病患者，其中31例（66%）为女孩。初诊平均年龄12.79±3.75岁。常见的主诉包括热不耐受（76.6%）、多汗（74.5%）、心悸（68.1%）、震颤（48.9%）、体重减轻（38.3%）、食欲增加（34%）、腹泻（31.9%）和便秘（4.3%）。平均促甲状腺素受体抗体滴度为16.93±13.47 IU/L。2例（4.3%）患者接受抗甲状腺药物治疗后缓解。结论：Graves病是青少年甲状腺功能亢进最常见的病因，治疗时应注意其体征和症状，以免延误治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Endocrinology Metabolism Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

2.90

自引率

5.90%

发文量

107

审稿时长

7 weeks

期刊介绍： The Archives of Endocrinology and Metabolism - AE&M – is the official journal of the Brazilian Society of Endocrinology and Metabolism - SBEM, which is affiliated with the Brazilian Medical Association. Edited since 1951, the AE&M aims at publishing articles on scientific themes in the basic translational and clinical area of Endocrinology and Metabolism. The printed version AE&M is published in 6 issues/year. The full electronic issue is open access in the SciELO - Scientific Electronic Library Online e at the AE&M site: www.aem-sbem.com. From volume 59 on, the name was changed to Archives of Endocrinology and Metabolism, and it became mandatory for manuscripts to be submitted in English for the online issue. However, for the printed issue it is still optional for the articles to be sent in English or Portuguese. The journal is published six times a year, with one issue every two months.