Sean V Connelly, Julia G Muller, Mohamed Ali, Billy E Ngasala, Wahida Hassan, Bakari Mohamed, Kyaw L Thwai, Jacob M Sadler, Jacob Marglous, Abebe A Fola, Abdallah Zacharia, Shija J Shija, Safia Mohammed, Msolo C Dominick, Hamza Said, Editruda E Peter, Melic Odas, Isaack J Rutha, Mwanaidi Nwange, Karamoko Naire, Shazia Ruybal-Pesántez, Robert Verity, Rebecca Crudale, Varun Goel, Barbara B Choloi, Anders Björkman, Jeffrey A Bailey, Jessica T Lin, Jonathan J Juliano
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引用次数: 0
Abstract
Artemisinin partial resistance (ART-R), driven by Plasmodium falciparum K13 mutations, threatens malaria control. Zanzibar is vulnerable to ART-R spread but lacks recent molecular surveillance. We sequenced samples in Zanzibar and mainland Tanzania collected in 2022-2024. K13 mutations (P441L, A675V) were found in 2/1440 Zanzibar participants and 6/3762 (R561H, P441L) in mainland Tanzania. K13 mutations appear to be of African origin and spreading regionally based on whole genome sequencing data. Frequent parasite importation appears to maintain partner drug mutation frequencies similar to the mainland, where artemether-lumefantrine selects for mutations favoring artesunate-amodiaquine sensitivity. Ongoing molecular surveillance remains essential to track these patterns.
期刊介绍：
Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.
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