METTL1 in human cancers: recognition of their functions, mechanisms and therapeutic value.

IF 5.2 Q2 ONCOLOGY

Oncology Reviews Pub Date : 2025-07-30 eCollection Date: 2025-01-01 DOI:10.3389/or.2025.1637372

Xinyu Zhang, Yuan Chen, Min Li, Xiaomeng Zhou, Qingcui Song

引用次数: 0

Abstract

Methyltransferase-like 1 (METTL1) is a methyltransferase that modulates the RNA methylation process and has been increasingly investigated in cancer research over the past decade. The review aims to summarize the diverse roles of METTL1 in various cancers, focusing on the mechanisms underlying tumorigenesis, progression, and metastasis. Furthermore, the therapeutic value and targeting strategies for METTL1 are also discussed to provide the foundation for further development of METTL1-targeted therapies. The article integrates recent research findings to highlight significant discoveries regarding METTL1, emphasizing its potential as a therapeutic target in cancer treatment.

查看原文本刊更多论文

METTL1在人类癌症中的作用、机制和治疗价值

甲基转移酶样1 （methyltransferase -like 1, METTL1）是一种调节RNA甲基化过程的甲基转移酶，在过去十年中在癌症研究中得到了越来越多的研究。本文旨在总结METTL1在各种癌症中的不同作用，重点关注肿瘤发生、进展和转移的机制。此外，本文还讨论了METTL1的治疗价值和靶向治疗策略，为进一步开发METTL1靶向治疗提供基础。本文整合了最近的研究成果，重点介绍了关于METTL1的重大发现，强调了其作为癌症治疗靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Oncology Reviews ONCOLOGY-

CiteScore

6.30

自引率

0.00%

发文量

审稿时长

9 weeks

期刊介绍： Oncology Reviews is a quarterly peer-reviewed, international journal that publishes authoritative state-of-the-art reviews on preclinical and clinical aspects of oncology. The journal will provide up-to-date information on the latest achievements in different fields of oncology for both practising clinicians and basic researchers. Oncology Reviews aims at being international in scope and readership, as reflected also by its Editorial Board, gathering the world leading experts in both pre-clinical research and everyday clinical practice. The journal is open for publication of supplements, monothematic issues and for publishing abstracts of scientific meetings; conditions can be obtained from the Editor-in-Chief or the publisher.