Predictors of botulinum toxin type A response in patients with migraine: a meta-analysis.

IF 1.5 4区 医学 Q3 CLINICAL NEUROLOGY
Shaoqi Wu, Chang Zhou
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引用次数: 0

Abstract

Background: Migraine is one of the most common neurological diseases, imposing a heavy burden on society. Botulinum toxin type A (BT-A) has been approved as a safe and effective preventive treatment; however, not all patients report effectiveness after BT-A treatment. Thus, identifying BT-A responders in advance is valuable for treatment. Several studies have shown that some characteristics of headache, like a shorter disease duration and the absence of medication overuse, are potential predictors of clinical response. This meta-analysis aims to identify predictors linked to BT-A in people with migraine.

Methods: PubMed, Web of Science, Embase and the Cochrane Library were searched for studies. All cohort studies reporting the factors of responders and non-responders to BT-A injection were selected.

Results: Eleven studies met the criteria for selection. Of the 18 factors identified, only six were reported in at least three studies. BT-A response was associated with disease duration (MD: -2.37, CI: [-4.03, -0.83], p = 0.0002). In sensitivity analysis, the outcome of headache days was also statistically significant (MD: 1.02, CI: [0.45, 1.59], p = 0.0004).

Conclusion: The findings of this meta-analysis support disease duration and headache days as predictive factors of BT-A response in people with migraine. Injecting BT-A at an early stage might be beneficial for migraine patients. However, the predictors were based on a small number of studies; thus, more studies are needed to prove the outcome. Several other factors may be associated with the response to BT-A but reported in a few studies. Therefore, more studies are needed to evaluate additional predictors.

偏头痛患者A型肉毒杆菌毒素反应的预测因素:荟萃分析。
背景:偏头痛是最常见的神经系统疾病之一,给社会造成了沉重的负担。A型肉毒杆菌毒素(BT-A)已被批准为一种安全有效的预防性治疗方法;然而,并非所有患者都报告BT-A治疗有效。因此,提前识别BT-A应答者对治疗是有价值的。几项研究表明,头痛的一些特征,如疾病持续时间较短和没有过度使用药物,是临床反应的潜在预测因素。这项荟萃分析旨在确定偏头痛患者与BT-A相关的预测因素。方法:检索PubMed、Web of Science、Embase和Cochrane图书馆。所有报告对BT-A注射有反应和无反应因素的队列研究都被选择。结果:11项研究符合入选标准。在确定的18个因素中,至少有3项研究报告了6个因素。BT-A反应与病程相关(MD: -2.37, CI: [-4.03, -0.83], p = 0.0002)。在敏感性分析中,头痛天数的结局也具有统计学意义(MD: 1.02, CI: [0.45, 1.59], p = 0.0004)。结论:本荟萃分析的结果支持疾病持续时间和头痛天数作为偏头痛患者BT-A反应的预测因素。早期注射BT-A可能对偏头痛患者有益。然而,这些预测是基于少量的研究;因此,需要更多的研究来证明这一结果。其他几个因素可能与对BT-A的反应有关,但在少数研究中报道。因此,需要更多的研究来评估其他预测因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Neurological Research
Neurological Research 医学-临床神经学
CiteScore
3.60
自引率
0.00%
发文量
116
审稿时长
5.3 months
期刊介绍: Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields. The scope of the journal includes: •Stem cell applications •Molecular neuroscience •Neuropharmacology •Neuroradiology •Neurochemistry •Biomathematical models •Endovascular neurosurgery •Innovation in neurosurgery.
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