Association between triglyceride-glucose index combinations and infertility: findings from a nationally representative study.

IF 2.7 3区医学 Q2 GENETICS & HEREDITY

Journal of Assisted Reproduction and Genetics Pub Date : 2025-08-14 DOI:10.1007/s10815-025-03618-y

Zi-Qi Dai, Ming-Yue Kong, Tian-Jiao Li, Xu-Jin Wu, Xue-Song Zhang, Rui Li, Xin Chen

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引用次数: 0

Abstract

Background: Infertility has emerged as a significant public health concern with implications for population development. Despite its relevance, there has been limited research addressing the association between infertility and triglyceride-glucose (TyG) index-derived indicators. This study examined the relationship between infertility and three TyG-related composite indices: TyG-BMI (TyG index combined with body mass index), TyG-WC (TyG index combined with waist circumference), and TyG-WHtR (TyG index combined with waist-to-height ratio).

Methods: Data were obtained from the 2013-2020 National Health and Nutrition Examination Survey, including a representative sample of 2856 adult participants. TyG-related indices were calculated using fasting triglyceride and glucose concentrations in combination with anthropometric measurements. Associations between infertility and TyG, TyG-BMI, TyG-WC, and TyG-WHtR were assessed using weighted multivariate logistic regression, subgroup analyses, smooth curve fitting, and threshold effect modeling.

Results: Significant positive associations were observed between infertility and TyG-BMI (odds ratio (OR), 1.003; 95% confidence interval (CI), 1.001-1.004), TyG-WC (OR, 1.001; 95% CI, 1.000-1.002), and TyG-WHtR (OR, 1.186; 95% CI, 1.058-1.329). Subgroup analyses indicated consistent positive associations within specific populations. Among Mexican American participants, all TyG-related indicators were significantly associated with infertility. In married participants and non-Hispanic White participants, TyG-BMI, TyG-WC, and TyG-WHtR demonstrated significant associations with infertility. Two-stage linear regression analyses did not depict any evidence of nonlinear relationships between these indices and infertility.

Conclusion: TyG-BMI, TyG-WC, and TyG-WHtR were identified as risk factors for infertility, with no observed nonlinear associations. These findings highlight the relevance of TyG-related metabolic indicators in reproductive health, warranting further investigation into their underlying pathophysiological mechanisms.

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甘油三酯-葡萄糖指数组合与不孕症之间的关系：一项具有全国代表性的研究结果。

背景：不孕症已成为影响人口发展的重大公共卫生问题。尽管其相关性，有有限的研究解决不孕不育和甘油三酯-葡萄糖（TyG）指数衍生指标之间的关系。本研究考察了三个与TyG相关的复合指标：TyG- bmi （TyG指数结合体重指数）、TyG- wc （TyG指数结合腰围）、TyG- whtr （TyG指数结合腰高比）与不孕症的关系。方法：数据来源于2013-2020年全国健康与营养检查调查，包括2856名成年人的代表性样本。使用空腹甘油三酯和葡萄糖浓度结合人体测量值计算tyg相关指数。不孕症与TyG、TyG- bmi、TyG- wc和TyG- whtr之间的关系采用加权多变量logistic回归、亚组分析、平滑曲线拟合和阈值效应建模进行评估。结果：不孕症与TyG-BMI呈显著正相关(优势比（OR）， 1.003；95%置信区间（CI）， 1.001-1.004), TyG-WC (OR, 1.001；95% CI, 1.000-1.002), TyG-WHtR (OR, 1.186；95% ci, 1.058-1.329)。亚组分析表明，在特定人群中存在一致的正相关。在墨西哥裔美国参与者中，所有tyg相关指标均与不孕症显著相关。在已婚参与者和非西班牙裔白人参与者中，TyG-BMI、TyG-WC和TyG-WHtR与不孕症有显著关联。两阶段线性回归分析没有描述这些指标与不孕症之间非线性关系的任何证据。结论：TyG-BMI、TyG-WC和TyG-WHtR被确定为不孕症的危险因素，没有观察到非线性关联。这些发现强调了tyg相关代谢指标与生殖健康的相关性，值得进一步研究其潜在的病理生理机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Assisted Reproduction and Genetics 医学-妇产科学

CiteScore

5.70

自引率

9.70%

发文量

286

审稿时长

1 months

期刊介绍： The Journal of Assisted Reproduction and Genetics publishes cellular, molecular, genetic, and epigenetic discoveries advancing our understanding of the biology and underlying mechanisms from gametogenesis to offspring health. Special emphasis is placed on the practice and evolution of assisted reproduction technologies (ARTs) with reference to the diagnosis and management of diseases affecting fertility. Our goal is to educate our readership in the translation of basic and clinical discoveries made from human or relevant animal models to the safe and efficacious practice of human ARTs. The scientific rigor and ethical standards embraced by the JARG editorial team ensures a broad international base of expertise guiding the marriage of contemporary clinical research paradigms with basic science discovery. JARG publishes original papers, minireviews, case reports, and opinion pieces often combined into special topic issues that will educate clinicians and scientists with interests in the mechanisms of human development that bear on the treatment of infertility and emerging innovations in human ARTs. The guiding principles of male and female reproductive health impacting pre- and post-conceptional viability and developmental potential are emphasized within the purview of human reproductive health in current and future generations of our species. The journal is published in cooperation with the American Society for Reproductive Medicine, an organization of more than 8,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.