Mitochondria and redox homeostasis - the backseat drivers in glioma.

IF 2.9 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Shruti Patrick, Ellora Sen
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引用次数: 0

Abstract

Mitochondrial function and redox regulatory processes are crucial aspects of cellular metabolism and energy production. Cancers, including gliomas, largely exhibit altered mitochondrial function, which can lead to changes in cellular signaling pathways and redox homeostasis. Aberrant redox signaling can promote glioma progression by influencing cell proliferation, metastasis, and therapeutic response. Several cancer-associated driver mutations - genetic alterations that confer survival and growth advantage to cancer cells, are associated with gliomas and affect mitochondrial function and redox states. Here is an overview of the crucial intersection between mitochondrial function and driver genes in glioma, highlighting some of the recent advances that augment our understanding of this intersection.

线粒体和氧化还原稳态-神经胶质瘤的后座驾驶员。
线粒体功能和氧化还原调节过程是细胞代谢和能量产生的关键方面。包括神经胶质瘤在内的癌症在很大程度上表现出线粒体功能的改变,这可能导致细胞信号通路和氧化还原稳态的改变。异常的氧化还原信号可以通过影响细胞增殖、转移和治疗反应来促进胶质瘤的进展。几种与癌症相关的驱动突变——赋予癌细胞生存和生长优势的基因改变,与胶质瘤有关,并影响线粒体功能和氧化还原状态。这里概述了胶质瘤中线粒体功能和驱动基因之间的关键交集,重点介绍了一些最近的进展,这些进展增强了我们对这种交集的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Free Radical Research
Free Radical Research 生物-生化与分子生物学
CiteScore
6.70
自引率
0.00%
发文量
47
审稿时长
3 months
期刊介绍: Free Radical Research publishes high-quality research papers, hypotheses and reviews in free radicals and other reactive species in biological, clinical, environmental and other systems; redox signalling; antioxidants, including diet-derived antioxidants and other relevant aspects of human nutrition; and oxidative damage, mechanisms and measurement.
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