Arran Sykes, Lisa Saalbach, Sam Benson, Eleni Nestoros, Rachael Tobin, Xin Yi, Michael G Tanner, Marc Vendrell, Gerald S Buller
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引用次数: 0
Abstract
Singlet-oxygen, the first excited state of molecular oxygen (O2), is a reactive oxygen species that plays a key role as a cytotoxic agent in photodynamic therapy (PDT). In this work, we report a highly light-sensitive detection system based on a single-photon avalanche diode (SPAD) detector and time-correlated single-photon counting (TCPSC) for real-time detection of luminescence signatures from photosensitized singlet-oxygen. Dynamics of singlet-oxygen produced by the excitation of small-scale organic nitrobenzoselenadiazole photosensitizers were extracted with acquisition times as short as 1 second. In a clinical setting, the ability to detect singlet-oxygen production in short time frames could allow for real-time adjustments in light dosing, ensuring sufficient singlet-oxygen production and complete treatment of diseased tissue in applications such as PDT.
期刊介绍：
The journal''s scope encompasses fundamental research, technology development, biomedical studies and clinical applications. BOEx focuses on the leading edge topics in the field, including:
Tissue optics and spectroscopy
Novel microscopies
Optical coherence tomography
Diffuse and fluorescence tomography
Photoacoustic and multimodal imaging
Molecular imaging and therapies
Nanophotonic biosensing
Optical biophysics/photobiology
Microfluidic optical devices
Vision research.
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