Scott MacKay, Suliman Alhaidari, Jared Cooper, Brendan Halloran, Michal Gozdzik
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引用次数: 0
Abstract
A 26-year-old man with Crohn's Disease (CD) presented to hospital with a CD flare after exposure to an anti-OX40 therapy (rocatinlimab) for eczema. This flare was characterized by upper gastrointestinal tract involvement and necrobiotic pulmonary nodules, a rare pulmonary manifestation of CD. Murine models have demonstrated mixed effects of anti-OX40 and anti-OX40 ligand therapies on colitis, and anti-OX40 therapy has been trialed in ulcerative colitis without significant clinical response seen. The impact of anti-OX40 therapies in patients with CD remains unclear, though this case suggests that caution may be required when using anti-OX40 therapies in this population.
期刊介绍：
ACG Case Reports Journal is a peer-reviewed, open-access publication that provides GI and hepatology fellows, private practice clinicians, and other healthcare providers an opportunity to share interesting case reports with their peers and with leaders in the field. ACG Case Reports Journal publishes case reports, images, videos and letters to the editor in all topics of gastroenterology and hepatology, including: Biliary Colon Endoscopy Esophagus Functional Bowel Disorders Inflammatory Bowel Disease Liver Nutrition and Obesity Pancreas Pathology Pediatric Small Bowel Stomach.
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