Shape transitions of red blood cell under oscillatory flows in microchannels.

IF 1.4 4区 物理与天体物理 Q4 MATERIALS SCIENCE, MULTIDISCIPLINARY
AIP Advances Pub Date : 2025-08-11 eCollection Date: 2025-08-01 DOI:10.1063/5.0278720
Lahcen Akerkouch, Trung Bao Le
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引用次数: 0

Abstract

This paper aims to examine the ability to control a model of red blood cell (RBC) dynamics and the associated extracellular flow patterns in microfluidic channels via oscillatory flows. Our computational approach employs a hybrid continuum-particle coupling, in which the cell membrane and cytosol fluid are modeled using the dissipative particle dynamics method. The blood plasma is modeled as an incompressible fluid via the immersed boundary method. This coupling is novel because it provides an accurate description of RBC dynamics while the extracellular flow patterns around the RBCs are also captured in detail. Our coupling methodology is validated with available experimental and computational data in the literature and shows excellent agreement. We explore the controlling regimes by varying the shape of the oscillatory flow waveform at the channel inlet. Our simulation results show that a host of RBC morphological dynamics emerges depending on the channel geometry, the incoming flow waveform, and the RBC initial location. Complex dynamics of RBC are induced by the flow waveform. Our results show that the RBC shape is strongly dependent on its initial location. Our results suggest that the controlling of oscillatory flows can be used to induce specific morphological shapes of RBCs and the surrounding fluid patterns in bio-engineering applications.

微通道内振荡流动下红细胞的形状转变。
本文旨在研究通过振荡流动控制微流体通道中红细胞(RBC)动力学模型和相关细胞外流动模式的能力。我们的计算方法采用混合连续-粒子耦合,其中细胞膜和细胞质流体使用耗散粒子动力学方法建模。采用浸入边界法将血浆建模为不可压缩流体。这种耦合是新颖的,因为它提供了红细胞动力学的准确描述,同时红细胞周围的细胞外流动模式也被详细捕获。我们的耦合方法通过文献中可用的实验和计算数据进行了验证,并显示出极好的一致性。我们通过改变通道入口的振荡流波形的形状来探索控制机制。我们的模拟结果表明,根据通道的几何形状、流入的流波形和RBC的初始位置,大量的RBC形态动态会出现。血流波形引起红细胞的复杂动力学。我们的结果表明,红细胞形状强烈依赖于其初始位置。我们的研究结果表明,在生物工程应用中,振荡流动的控制可以用来诱导红细胞的特定形态和周围的流体模式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
AIP Advances
AIP Advances NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY
CiteScore
2.80
自引率
6.20%
发文量
1233
审稿时长
2-4 weeks
期刊介绍: AIP Advances is an open access journal publishing in all areas of physical sciences—applied, theoretical, and experimental. All published articles are freely available to read, download, and share. The journal prides itself on the belief that all good science is important and relevant. Our inclusive scope and publication standards make it an essential outlet for scientists in the physical sciences. AIP Advances is a community-based journal, with a fast production cycle. The quick publication process and open-access model allows us to quickly distribute new scientific concepts. Our Editors, assisted by peer review, determine whether a manuscript is technically correct and original. After publication, the readership evaluates whether a manuscript is timely, relevant, or significant.
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