Trends, Social Determinants, and Lifestyle Factors Associated With Comorbidity of Diabetes and Kidney Diseases Among Chinese Adults Aged ≥ 45 Years

IF 3.7 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Pub Date : 2025-08-15 DOI:10.1111/1753-0407.70142

Guanghui Cui, Shaojie Li, Yu Qin, Yuqin Zhang, Kunpeng Hui, Mengfan Feng, Weiwei Li, Xuezhi Zhang

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引用次数: 0

Abstract

Objectives

The dual burden of diabetes and kidney disease poses a growing public health challenge in aging populations, yet its longitudinal trends and modifiable determinants in China remain understudied. This study aims to track the trends in the prevalence of the comorbidity of diabetes and kidney disease in Chinese middle-aged and older adults over a 10-year period (2011–2020) and identify social determinants and lifestyle factors associated with this comorbidity.

Methods

This study utilized data from five waves of the China Health and Retirement Longitudinal Study (CHARLS). Temporal trends and geographical distributions of the comorbidity of diabetes and kidney diseases were analyzed across survey years; disaggregated by sex, residence, and geographical region. Cox proportional hazards regression models were employed to explore the associations between SDOH burden, lifestyle factors, and the risk of comorbidity.

Results

The prevalence of diabetes and kidney disease comorbidity exhibited a clear upward trend among Chinese adults aged ≥ 45 years, increasing from 0.60% in 2011 to 3.10% in 2020. Geographical analysis revealed significant regional disparities, with Northeast China having the highest prevalence throughout the decade (4.76% in 2020). High SDOH burden was associated with an increased risk of comorbidity (HR = 1.24, 95% CI = 1.01–1.52). Conversely, maintaining a good (HR = 0.38, 95% CI = 0.27–0.54) or moderate (HR = 0.74, 95% CI = 0.59–0.91) lifestyle was associated with a reduced risk.

Conclusion

The rising prevalence and significant regional disparities of diabetes and kidney disease comorbidity underscore the urgent need for targeted public health interventions in China.

Abstract Image

查看原文本刊更多论文

中国≥45岁成人糖尿病和肾病共病的趋势、社会决定因素和生活方式因素

糖尿病和肾脏疾病的双重负担给老龄化人口带来了越来越大的公共卫生挑战，但其在中国的纵向趋势和可改变的决定因素仍未得到充分研究。本研究旨在追踪10年间（2011-2020年）中国中老年人糖尿病和肾脏疾病合并症的流行趋势，并确定与这种合并症相关的社会决定因素和生活方式因素。方法本研究利用中国健康与退休纵向研究（CHARLS）的五波数据。分析了糖尿病和肾脏疾病合并症的时间趋势和地理分布；按性别、居住地和地理区域分列。采用Cox比例风险回归模型探讨SDOH负担、生活方式因素与合并症风险之间的关系。结果中国≥45岁成人糖尿病和肾脏疾病合并症患病率呈明显上升趋势，从2011年的0.60%上升到2020年的3.10%。区域差异显著，东北地区10年患病率最高（2020年为4.76%）。高SDOH负担与合并症风险增加相关（HR = 1.24, 95% CI = 1.01-1.52）。相反，保持良好（HR = 0.38, 95% CI = 0.27-0.54）或适度（HR = 0.74, 95% CI = 0.59-0.91）的生活方式与降低风险相关。结论糖尿病和肾脏疾病合并症患病率的上升和显著的地区差异突出了中国迫切需要有针对性的公共卫生干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

2.20%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.