Illuminating gene delivery: Insights into the light-induced gene delivery systems with emphasis on mRNA therapeutics

IF 22 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Today Pub Date : 2025-07-07 DOI:10.1016/j.mattod.2025.06.034

Yongyi Xie , You Zhou , Jiaxin Guo , Zhongqian Zhang , Yongcheng Zhu , Ewa M. Goldys , Wei Deng , Wenjie Chen

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Abstract

Gene therapy has seen both challenges and important breakthroughs, pointing to its vast potential and a bright future. Gene therapies, which enable the expression of therapeutic proteins by regulating diseased genes, offer the potential to cure conditions untreatable by conventional drugs. However, despite their promise, gene therapies face major delivery challenges, such as limited precision, targeting specificity, and delivery efficiency. Among the various stimulus-responsive strategies, light-induced gene delivery systems stand out as a promising solution to these hurdles. Utilizing light-triggered mechanisms can help overcome some of the key limitations of gene therapy. The combination of gene therapy with phototherapy shows great potential for clinical applications. This paper reviews the principles, mechanisms, applications, and future directions of light-assisted gene delivery systems, with a special focus on emerging mRNA therapeutics, offering new insights into this evolving field.

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启发基因传递：洞察光诱导基因传递系统，重点是mRNA治疗

基因治疗既有挑战，也有重大突破，显示出巨大的潜力和光明的前景。基因疗法通过调节患病基因使治疗性蛋白得以表达，为治愈传统药物无法治疗的疾病提供了可能。然而，尽管前景光明，基因疗法面临着主要的递送挑战，如有限的精度、靶向特异性和递送效率。在各种刺激反应策略中，光诱导基因传递系统作为解决这些障碍的有希望的解决方案脱颖而出。利用光触发机制可以帮助克服基因治疗的一些关键限制。基因治疗与光疗相结合具有广阔的临床应用前景。本文综述了光辅助基因传递系统的原理、机制、应用和未来发展方向，重点介绍了新兴的mRNA治疗方法，为这一不断发展的领域提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials Today 工程技术-材料科学：综合

CiteScore

36.30

自引率

1.20%

发文量

237

审稿时长

23 days

期刊介绍： Materials Today is the leading journal in the Materials Today family, focusing on the latest and most impactful work in the materials science community. With a reputation for excellence in news and reviews, the journal has now expanded its coverage to include original research and aims to be at the forefront of the field. We welcome comprehensive articles, short communications, and review articles from established leaders in the rapidly evolving fields of materials science and related disciplines. We strive to provide authors with rigorous peer review, fast publication, and maximum exposure for their work. While we only accept the most significant manuscripts, our speedy evaluation process ensures that there are no unnecessary publication delays.