WNT7A

IF 2.6 3区生物学 Q4 CELL BIOLOGY

Differentiation Pub Date : 2025-08-07 DOI:10.1016/j.diff.2025.100899

Naomi M. Calhoun, Richard R. Behringer

引用次数: 0

Abstract

WNT7A regulates numerous developmental processes. It can activate canonical and non-canonical signaling depending on context. It is expressed in the developing central nervous system, limb buds, reproductive organs, and other tissues. Spontaneous and targeted Wnt7a mutations in mouse models resulted in abnormal limbs, defects in male and female reproductive tract organs, infertility, and defects in cerebellar axon remodeling. In zebrafish, wnt7aa mutants exhibited neurogenesis and angiogenesis defects in the central nervous system. In humans, recessive WNT7A missense and nonsense mutations resulted in severe limb and pelvic bone defects. Alterations in WNT7A expression correlated with multiple types of cancer.

查看原文本刊更多论文

WNT7A调控许多发育过程。它可以根据上下文激活规范和非规范信号。它在发育中的中枢神经系统、肢体芽、生殖器官和其他组织中表达。小鼠模型中自发和靶向的Wnt7a突变导致四肢异常、雄性和雌性生殖道器官缺陷、不育和小脑轴突重塑缺陷。在斑马鱼中，wnt7aa突变体在中枢神经系统中表现出神经发生和血管生成缺陷。在人类中，隐性WNT7A错义和无义突变导致严重的肢体和骨盆骨缺损。WNT7A表达的改变与多种类型的癌症相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Differentiation 生物-发育生物学

CiteScore

4.10

自引率

3.40%

发文量

审稿时长

51 days

期刊介绍： Differentiation is a multidisciplinary journal dealing with topics relating to cell differentiation, development, cellular structure and function, and cancer. Differentiation of eukaryotes at the molecular level and the use of transgenic and targeted mutagenesis approaches to problems of differentiation are of particular interest to the journal. The journal will publish full-length articles containing original work in any of these areas. We will also publish reviews and commentaries on topics of current interest. The principal subject areas the journal covers are: • embryonic patterning and organogenesis • human development and congenital malformation • mechanisms of cell lineage commitment • tissue homeostasis and oncogenic transformation • establishment of cellular polarity • stem cell differentiation • cell reprogramming mechanisms • stability of the differentiated state • cell and tissue interactions in vivo and in vitro • signal transduction pathways in development and differentiation • carcinogenesis and cancer • mechanisms involved in cell growth and division especially relating to cancer • differentiation in regeneration and ageing • therapeutic applications of differentiation processes.