{"title":"A systematic review on cow ghee formulations anti-epileptic activity in in-vivo models","authors":"Nidhin M M , Bharat Rathi","doi":"10.1016/j.prenap.2025.100343","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Consciousness disruptions and recurring seizures are hallmarks of epilepsy, a chronic neurological disorder. It shares similarities with the Ayurvedic notion of <em>Apasmara</em>, which is marked by intermittent unconsciousness, uncomfortable symptoms such frothy vomiting, and unusual body postures.</div><div>According to <em>Ayurveda</em>, <em>Ghrita</em> (Ghee), especially <em>Go Ghrita</em> (Cow Ghee), which is made from cow's milk, is a nutritious diet and medication with therapeutic benefits.<em>Go Ghrita</em> is extremely valuable, because of its ability to maintain the <em>Pitta</em> and <em>Vata Doshas</em> in balance and because of its lipophilic qualities, which allow it to pass through the blood-brain barrier for more targeted administration and absorption. The ‘<em>Rasayana’</em> characteristic of <em>Go Ghrita</em> implies that regular use may help lower the likelihood of epilepsy recurrence. <em>Ghrita</em> improves the medicinal qualities of pharmaceuticals when it is processed, which could make formulations using <em>Go Ghrita</em> more beneficial and effective for treating epilepsy.</div></div><div><h3>Aim</h3><div>To do A Systematic Review on Cow Ghee Formulations <em>(Go Ghrita kalpana</em>) Anti-Epileptic Activity in In-Vivo Models</div></div><div><h3>Methodology</h3><div>The systematic review exclusively included in-vivo animal research on the antiepileptic efficacy of Cow Ghee Formulations <em>(Go Ghrita kalpana)</em>. The study papers and journal studies were sourced from resources like PubMed, Science Direct, and Google Scholar. These databases serve as the foundation for the rapid review process's selection of research articles and journals.</div></div><div><h3>Result & conclusion</h3><div>Thirty studies were discovered after 11 studies were chosen using the selection strategy. All of the studies that were chosen for the systematic review did so due to the noteworthy antiepileptic effects of different <em>Ghrita Kalpana</em>.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100343"},"PeriodicalIF":0.0000,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological Research - Natural Products","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2950199725002034","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction
Consciousness disruptions and recurring seizures are hallmarks of epilepsy, a chronic neurological disorder. It shares similarities with the Ayurvedic notion of Apasmara, which is marked by intermittent unconsciousness, uncomfortable symptoms such frothy vomiting, and unusual body postures.
According to Ayurveda, Ghrita (Ghee), especially Go Ghrita (Cow Ghee), which is made from cow's milk, is a nutritious diet and medication with therapeutic benefits.Go Ghrita is extremely valuable, because of its ability to maintain the Pitta and Vata Doshas in balance and because of its lipophilic qualities, which allow it to pass through the blood-brain barrier for more targeted administration and absorption. The ‘Rasayana’ characteristic of Go Ghrita implies that regular use may help lower the likelihood of epilepsy recurrence. Ghrita improves the medicinal qualities of pharmaceuticals when it is processed, which could make formulations using Go Ghrita more beneficial and effective for treating epilepsy.
Aim
To do A Systematic Review on Cow Ghee Formulations (Go Ghrita kalpana) Anti-Epileptic Activity in In-Vivo Models
Methodology
The systematic review exclusively included in-vivo animal research on the antiepileptic efficacy of Cow Ghee Formulations (Go Ghrita kalpana). The study papers and journal studies were sourced from resources like PubMed, Science Direct, and Google Scholar. These databases serve as the foundation for the rapid review process's selection of research articles and journals.
Result & conclusion
Thirty studies were discovered after 11 studies were chosen using the selection strategy. All of the studies that were chosen for the systematic review did so due to the noteworthy antiepileptic effects of different Ghrita Kalpana.