Ali Rajabiyan*, Danial Bakhshi and Seyed Abolfazl Hosseini,
{"title":"A Methodological Review of Extraction, Purification, and Identification Techniques for Natural Bioactive Compounds","authors":"Ali Rajabiyan*, Danial Bakhshi and Seyed Abolfazl Hosseini, ","doi":"10.1021/acs.oprd.5c00080","DOIUrl":null,"url":null,"abstract":"<p >Natural resources, both land and sea, contain many bioactive compounds. Today, these compounds have attracted the attention of many researchers due to their many therapeutic, medical, and other industrial applications. Due to their important health effects, extracting, purifying, and identifying the properties and structural descriptions of natural compounds show great attention in their analytical science. A crucial initial step in generating high-quality research results is preparing medicinal plants for testing. Prior to performing the intended biological test, biologically active chemicals must be extracted, purified, and their concentration and purity determined. Examples of popular extraction methods include percolation, Soxhlet, maceration, ultrasonic, enzymatic, and microwave extraction. On the other hand, the separation and purification of herbal substances is accomplished using numerous very efficient chromatography methods, including thin-layer chromatography, gas chromatography, and liquid chromatography. Ultimately, the resulting compounds are characterized using a range of identification techniques, like nuclear magnetic resonance spectroscopy, infrared spectroscopy, ultraviolet spectroscopy, and mass spectrometry. Here we review and provide an invaluable tool for researchers, business leaders, and legislators seeking to use natural bioactive chemicals to promote human health and environmental sustainability.</p>","PeriodicalId":55,"journal":{"name":"Organic Process Research & Development","volume":"29 8","pages":"1885–1915"},"PeriodicalIF":3.5000,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Process Research & Development","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.oprd.5c00080","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Natural resources, both land and sea, contain many bioactive compounds. Today, these compounds have attracted the attention of many researchers due to their many therapeutic, medical, and other industrial applications. Due to their important health effects, extracting, purifying, and identifying the properties and structural descriptions of natural compounds show great attention in their analytical science. A crucial initial step in generating high-quality research results is preparing medicinal plants for testing. Prior to performing the intended biological test, biologically active chemicals must be extracted, purified, and their concentration and purity determined. Examples of popular extraction methods include percolation, Soxhlet, maceration, ultrasonic, enzymatic, and microwave extraction. On the other hand, the separation and purification of herbal substances is accomplished using numerous very efficient chromatography methods, including thin-layer chromatography, gas chromatography, and liquid chromatography. Ultimately, the resulting compounds are characterized using a range of identification techniques, like nuclear magnetic resonance spectroscopy, infrared spectroscopy, ultraviolet spectroscopy, and mass spectrometry. Here we review and provide an invaluable tool for researchers, business leaders, and legislators seeking to use natural bioactive chemicals to promote human health and environmental sustainability.
期刊介绍：
The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.
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