A conserved RNA motif guides DCL1-mediated cleavage in plant microRNA biogenesis

Abstract

A conserved GHR motif is shown to guide the DCL1-mediated cleavage of pre-miRNAs during plant miRNA biogenesis. This discovery advances our understanding of the mechanisms underlying RNA processing and, as cleavage at this motif results in the production of known non-canonical miRNAs, offers insights into miRNA maturation and function.