Umbilical Cord Mesenchymal Stem Cells as a Meritorious Option to Treat Psoriasis.

IF 2.2

Current stem cell research & therapy Pub Date : 2025-08-11 DOI:10.2174/011574888X382147250801101300

Reza Arefnezhad, Saleheh Jahani, Aram Alipour, Dorrin Alipour Amini, Mohammad Mahdi Safarpour, Sharareh Jahangiri, Arian Karimi Rouzbahani, Hooman Zarei, Fatemeh Rezaei-Tazangi

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Abstract

Psoriasis is a chronic immune-mediated disease that affects a significant percentage of the global population. The pathogenesis of psoriasis involves the rapid turnover of skin cells and immune system dysregulation, particularly the T cell-mediated autoimmune response. Conventional treatments for Psoriasis include topical therapy, light therapy (phototherapy), and systemic medications; however, some limitations and diverse side effects have been mentioned for their usage. Therefore, increasing attention is being directed toward finding alternative therapeutic methods for psoriasis. Recently, Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) have gained attention for their potential in treating various diseases, including autoimmune disorders, cardiovascular conditions, and metabolic disorders. Multiple advantages have been reported for UC-MSCs, including noninvasive collection, low immunogenicity, and minimal ethical issues. The aim of this review was to explore the potential of UC-MSCs in the treatment of psoriasis.

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脐带间充质干细胞作为治疗银屑病的有利选择。

牛皮癣是一种慢性免疫介导的疾病，影响着全球人口的很大一部分。牛皮癣的发病机制涉及皮肤细胞的快速更新和免疫系统失调，特别是T细胞介导的自身免疫反应。银屑病的常规治疗包括局部治疗、光治疗和全身药物治疗；然而，它们的使用也有一些局限性和不同的副作用。因此，人们越来越关注牛皮癣的替代治疗方法。最近，脐带间充质干细胞（UC-MSCs）因其治疗多种疾病的潜力而受到关注，包括自身免疫性疾病、心血管疾病和代谢紊乱。据报道，UC-MSCs具有多种优势，包括无创采集、低免疫原性和最小的伦理问题。本综述的目的是探讨UC-MSCs治疗牛皮癣的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Current stem cell research & therapy

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