Effect of L-shaped, loosely packed versus non-trimmed, compactly packed non-fixed collagenated bone blocks on the stability of augmented sites in chronic peri-implant dehiscence defects: a pre-clinical in vivo experimental study.

IF 3.2 4区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE
Dong-Woon Lee, Jae-Hong Lee
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引用次数: 0

Abstract

Purpose: This pre-clinical study aimed to compare the efficacy of L-shaped, loosely packed soft block bone substitutes (BBS, LP group) with that of non-trimmed, compactly packed soft BBS (CP group), both covered with a non-fixed collagen membrane, on augmentation stability and new bone formation in chronic peri-implant dehiscence defects treated with guided bone regeneration (GBR).

Methods: In 4 mongrel dogs, 4 standardized box-shaped buccal defects were surgically created in each jaw. Following a 4-week period of spontaneous healing, a total of 32 dental implants were placed, with 2 implants inserted into each defect. Each defect was randomly assigned to either the LP or CP group. Statistical comparisons between groups were conducted using the Mann-Whitney U test. Bland-Altman and Spearman correlation analyses were also performed to evaluate the relationship and agreement between micro-computed tomography (micro-CT) and histomorphometric measurements.

Results: Micro-CT and histomorphometric analyses revealed no significant differences in bone width at any apical level between the LP and CP groups. Both groups exhibited similar increases in bone width, although bone retention in the coronal region remained limited. Additionally, micro-CT tended to slightly overestimate bone width (mean difference, 0.31 mm), but showed a strong correlation with histomorphometric analysis (r=0.971, P<0.001), supporting the reliability of radiographic methods for bone assessment.

Conclusions: Neither LP nor CP soft BBS effectively prevented morphological collapse in the coronal region of augmented sites when used without additional membrane fixation. These findings underscore the necessity of enhanced stabilization techniques to improve structural integrity and bone regeneration in GBR procedures.

l形松散填充与非修整紧密填充的非固定骨块对慢性种植体周围开裂缺陷增强部位稳定性的影响:临床前体内实验研究
目的:本临床前研究旨在比较l形、松散填充的软块骨替代物(BBS, LP组)与非修整、紧凑填充的软块骨替代物(CP组)在引导骨再生(GBR)治疗慢性种植体周围开裂缺陷的增强稳定性和新骨形成方面的疗效。方法:选取4只杂种犬,在每只下颚分别手术制造4个标准化盒状颊缺损。在4周的自然愈合期后,共放置32颗种植体,每个缺损植入2颗种植体。每个缺陷被随机分配到LP组或CP组。组间比较采用Mann-Whitney U检验。还进行了Bland-Altman和Spearman相关分析,以评估微计算机断层扫描(micro-CT)和组织形态学测量之间的关系和一致性。结果:显微ct和组织形态学分析显示,LP组和CP组在任何根尖水平的骨宽度均无显著差异。两组均表现出相似的骨宽度增加,尽管冠状区骨保留仍然有限。此外,微ct倾向于略微高估骨宽度(平均差值为0.31 mm),但与组织形态学分析有很强的相关性(r=0.971, p)。结论:在没有额外膜固定的情况下使用LP和CP软BBS均不能有效防止冠状区增强部位的形态塌陷。这些发现强调了在GBR手术中加强稳定技术以提高结构完整性和骨再生的必要性。
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来源期刊
Journal of Periodontal and Implant Science
Journal of Periodontal and Implant Science DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
3.30
自引率
5.30%
发文量
38
期刊介绍: Journal of Periodontal & Implant Science (JPIS) is a peer-reviewed and open-access journal providing up-to-date information relevant to professionalism of periodontology and dental implantology. JPIS is dedicated to global and extensive publication which includes evidence-based original articles, and fundamental reviews in order to cover a variety of interests in the field of periodontal as well as implant science.
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