White Matter Integrity of the Three Subdivisions of the Superior Longitudinal Fasciculi in First-Episode Psychosis Patients.

IF 1.8 4区医学 Q3 PSYCHIATRY

Psychiatry Investigation Pub Date : 2025-09-01 Epub Date: 2025-08-14 DOI:10.30773/pi.2025.0116

Jongrak Kim, Hyungyou Park, Inkyung Park, Jiseon Jang, Minah Kim, Jun Soo Kwon

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引用次数: 0

Abstract

Objective: The superior longitudinal fasciculus (SLF) is a white matter (WM) bundle connecting the frontal and parietal lobes. SLF subdivisions have distinct functions (e.g., attention, working memory, and language processing), and abnormalities in specific subdivisions may differentially contribute to the pathophysiology of first-episode psychosis (FEP). However, previous diffusion magnetic resonance imaging (MRI) studies have not fully examined SLF subdivisions, limiting our understanding of their role in FEP patients. The aim of this study was to assess whether WM integrity differs in SLF subdivisions between FEP patients and healthy controls (HCs) using advanced diffusion tensor imaging.

Methods: 3T diffusion MRI scans were obtained from 39 FEP patients and 110 HCs. Deterministic tractography was used to reconstruct the three SLF subdivisions (SLF I, II, and III). We analyzed the fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) of these subdivisions and compared the results between FEP patients and HCs.

Results: There were no significant group differences in the FA, MD, or RD between the FEP patients and HCs.

Conclusion: No significant differences in WM integrity between FEP patients and HCs were found. These results suggest that significant WM changes may develop later in the disease course rather than in the early stages of psychotic disorders such as FEP.

Abstract Image

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首发精神病患者上纵束神经束三个分支的白质完整性。

目的：上纵束（SLF）是连接额叶和顶叶的白质束。SLF细分具有不同的功能（例如，注意、工作记忆和语言处理），特定细分的异常可能对首发精神病（FEP）的病理生理有不同的贡献。然而，先前的扩散磁共振成像（MRI）研究并没有完全检查SLF细分，限制了我们对其在FEP患者中的作用的理解。本研究的目的是利用先进的弥散张量成像技术评估FEP患者和健康对照（hc）之间SLF细分的WM完整性是否存在差异。方法：对39例FEP患者和110例hc患者进行3T弥散MRI扫描。采用确定性泪道造影重建三个SLF细分（SLF I、II和III）。我们分析了这些细分的分数各向异性（FA）、平均扩散率（MD）和径向扩散率（RD），并比较了FEP患者和hcc患者的结果。结果：FEP患者和hcc患者在FA、MD或RD方面没有显著的组间差异。结论：FEP患者与hcc患者的WM完整性无显著差异。这些结果表明，显著的WM变化可能发生在病程的后期，而不是在精神障碍如FEP的早期阶段。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatry Investigation PSYCHIATRY-

CiteScore

4.10

自引率

3.70%

发文量

105

审稿时长

6-12 weeks

期刊介绍： The Psychiatry Investigation is published on the 25th day of every month in English by the Korean Neuropsychiatric Association (KNPA). The Journal covers the whole range of psychiatry and neuroscience. Both basic and clinical contributions are encouraged from all disciplines and research areas relevant to the pathophysiology and management of neuropsychiatric disorders and symptoms, as well as researches related to cross cultural psychiatry and ethnic issues in psychiatry. The Journal publishes editorials, review articles, original articles, brief reports, viewpoints and correspondences. All research articles are peer reviewed. Contributions are accepted for publication on the condition that their substance has not been published or submitted for publication elsewhere. Authors submitting papers to the Journal (serially or otherwise) with a common theme or using data derived from the same sample (or a subset thereof) must send details of all relevant previous publications and simultaneous submissions. The Journal is not responsible for statements made by contributors. Material in the Journal does not necessarily reflect the views of the Editor or of the KNPA. Manuscripts accepted for publication are copy-edited to improve readability and to ensure conformity with house style.