In Situ: Microbial Aerodynamic Microneedles for Targeted Drug Delivery Systems.

IF 10.7 1区综合性期刊 Q1 Multidisciplinary

Research Pub Date : 2025-08-12 eCollection Date: 2025-01-01 DOI:10.34133/research.0775

Chenyu Zong, Fei Wang, Wenguo Cui

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引用次数: 0

Abstract

In situ microbial aerodynamic microneedles (MM-MNs) represent an autonomous transdermal drug delivery platform that utilizes the gas generated by microbial metabolism (e.g., H₂, NO, and H₂S) to propel drugs into deep tissues, surpassing the penetration limits of traditional microneedles reliant on external stimuli (heat/light/mechanical force). By leveraging controlled microbial metabolism, MM-MNs enable energy-independent, spatiotemporally precise delivery with enhanced targeting and bioavailability. Gas-driven propulsion combines with bioactive gas functions (e.g., NO-induced vasodilation and H₂S-mediated anti-inflammation) to modulate disease microenvironments. The system's biocompatibility (probiotic strains and Lactobacillus) and scalability (cost-effective patch design) further support its potential for localized therapies (skin diseases and tumors) with minimized systemic exposure. This innovation bridges microbial biotechnology and precision medicine, offering a paradigm shift in transdermal delivery.

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原位：用于靶向药物输送系统的微生物气动微针。

原位微生物气动微针（MM-MNs）是一种自主透皮给药平台，它利用微生物代谢产生的气体（如H2、NO和H2S）将药物推进到组织深处，超越了传统微针依赖外部刺激（热/光/机械力）的穿透限制。通过利用受控的微生物代谢，MM-MNs能够实现能量独立、时空精确的递送，并具有增强的靶向性和生物利用度。气体驱动推进结合生物活性气体功能（如no诱导的血管扩张和h2s介导的抗炎症）来调节疾病微环境。该系统的生物相容性（益生菌菌株和乳酸杆菌）和可扩展性（具有成本效益的贴片设计）进一步支持了其局部治疗（皮肤病和肿瘤）的潜力，同时最小化了全身暴露。这一创新连接了微生物生物技术和精准医学，提供了透皮给药的范式转变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Research Multidisciplinary-Multidisciplinary

CiteScore

13.40

自引率

3.60%

发文量

审稿时长

14 weeks

期刊介绍： Research serves as a global platform for academic exchange, collaboration, and technological advancements. This journal welcomes high-quality research contributions from any domain, with open arms to authors from around the globe. Comprising fundamental research in the life and physical sciences, Research also highlights significant findings and issues in engineering and applied science. The journal proudly features original research articles, reviews, perspectives, and editorials, fostering a diverse and dynamic scholarly environment.