A Society-to-Cells approach to evaluating multilevel and interrelated drivers of breast cancer disparities in Black women.

IF 7.6 2区医学 Q1 ONCOLOGY

NPJ Breast Cancer Pub Date : 2025-08-13 DOI:10.1038/s41523-025-00812-0

Maurade Gormley, Wayne R Lawrence, Jesse J Plascak, Electra D Paskett, Coral Omene, Adana A M Llanos

引用次数: 0

Abstract

Despite advances in detection and treatment, Black women in the US continue to experience more aggressive breast cancer subtypes and higher mortality. Framed through a Society-to-Cells lens, this review presents a comprehensive framework for understanding how multilevel drivers-from structural forces to cellular responses-interact to perpetuate disparities. Addressing these inequities requires systemic reforms targeting root causes, including policies to redress historical neighborhood disinvestment and eliminate bias within healthcare systems.

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从社会到细胞的方法来评估黑人妇女乳腺癌差异的多层次和相关驱动因素。

尽管在检测和治疗方面取得了进步，但美国黑人女性的乳腺癌亚型更具侵袭性，死亡率也更高。通过从社会到细胞的视角，本文提出了一个全面的框架，以理解从结构力量到细胞反应的多层次驱动因素如何相互作用，从而使差异持续存在。解决这些不平等问题需要针对根本原因进行系统性改革，包括纠正历史上的社区撤资和消除医疗保健系统内的偏见的政策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Breast Cancer Medicine-Pharmacology (medical)

CiteScore

10.10

自引率

1.70%

发文量

122

审稿时长

9 weeks

期刊介绍： npj Breast Cancer publishes original research articles, reviews, brief correspondence, meeting reports, editorial summaries and hypothesis generating observations which could be unexplained or preliminary findings from experiments, novel ideas, or the framing of new questions that need to be solved. Featured topics of the journal include imaging, immunotherapy, molecular classification of disease, mechanism-based therapies largely targeting signal transduction pathways, carcinogenesis including hereditary susceptibility and molecular epidemiology, survivorship issues including long-term toxicities of treatment and secondary neoplasm occurrence, the biophysics of cancer, mechanisms of metastasis and their perturbation, and studies of the tumor microenvironment.