Wenjie Zhou, Ting Feng, Liman Li, Zhuoxu He, Yueli Mu, Dong Liu, Hong Li
{"title":"γδ T cells in pediatric sepsis.","authors":"Wenjie Zhou, Ting Feng, Liman Li, Zhuoxu He, Yueli Mu, Dong Liu, Hong Li","doi":"10.1093/jleuko/qiaf118","DOIUrl":null,"url":null,"abstract":"<p><p>Pediatric sepsis has constantly increased over the world, and is now a leading cause of children's morbidity and mortality. Due to this alarming trend, intense research has been sparked into the unique characteristics of pediatric sepsis, the mechanisms behind the immune dysfunction, and opportunities for improving treatment. Recent findings have underscored the critical role of γδ T cells in the immune response, and their dysfunction has been linked to various diseases, including pediatric sepsis. This review explores γδ T-cell dysfunction in pediatric sepsis, focusing on their impaired activation, proliferation, altered cytokine production, exhaustion, and apoptosis, all of which collectively weaken the immune response in children. The review underscores the significance of γδ T-cell immunology in pediatric sepsis and highlights the notable functional disparities between children and adults. Ongoing research is essential to fully understand the role of γδ T cells in the pathogenesis of sepsis and to develop more effective treatments that will enhance outcomes for affected children.</p>","PeriodicalId":16186,"journal":{"name":"Journal of Leukocyte Biology","volume":" ","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Leukocyte Biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/jleuko/qiaf118","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Pediatric sepsis has constantly increased over the world, and is now a leading cause of children's morbidity and mortality. Due to this alarming trend, intense research has been sparked into the unique characteristics of pediatric sepsis, the mechanisms behind the immune dysfunction, and opportunities for improving treatment. Recent findings have underscored the critical role of γδ T cells in the immune response, and their dysfunction has been linked to various diseases, including pediatric sepsis. This review explores γδ T-cell dysfunction in pediatric sepsis, focusing on their impaired activation, proliferation, altered cytokine production, exhaustion, and apoptosis, all of which collectively weaken the immune response in children. The review underscores the significance of γδ T-cell immunology in pediatric sepsis and highlights the notable functional disparities between children and adults. Ongoing research is essential to fully understand the role of γδ T cells in the pathogenesis of sepsis and to develop more effective treatments that will enhance outcomes for affected children.
期刊介绍:
JLB is a peer-reviewed, academic journal published by the Society for Leukocyte Biology for its members and the community of immunobiologists. The journal publishes papers devoted to the exploration of the cellular and molecular biology of granulocytes, mononuclear phagocytes, lymphocytes, NK cells, and other cells involved in host physiology and defense/resistance against disease. Since all cells in the body can directly or indirectly contribute to the maintenance of the integrity of the organism and restoration of homeostasis through repair, JLB also considers articles involving epithelial, endothelial, fibroblastic, neural, and other somatic cell types participating in host defense. Studies covering pathophysiology, cell development, differentiation and trafficking; fundamental, translational and clinical immunology, inflammation, extracellular mediators and effector molecules; receptors, signal transduction and genes are considered relevant. Research articles and reviews that provide a novel understanding in any of these fields are given priority as well as technical advances related to leukocyte research methods.