Obesity‑related kidney disease: a review on ultrasound applications.

IF 3.1 3区 医学 Q1 PEDIATRICS
Armando Di Ludovico, Costanza Pucci, Giovanni Grassi, Gian Luca Chabert, Giuseppe Ledda, Ilaria Mascioli, Saverio La Bella, Francesca Ciarelli, Luciana Breda, Cosimo Giannini, Angelika Mohn, Francesco Chiarelli, Antonio Corsello
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Abstract

Pediatric obesity is a growing global health concern, associated with metabolic, cardiovascular, and kidney complications. Early identification and intervention are crucial to preventing long-term morbidity. This review examines the epidemiology, pathophysiology, and clinical implications of childhood obesity, focusing on its impact on kidney health. We discuss non-invasive diagnostic tools, including kidney ultrasound, and evidence-based management strategies. Obesity in children is linked to hypertension, insulin resistance, and early signs of kidney dysfunction, including increased kidney echogenicity and hyperfiltration. Ultrasound findings may serve as early markers of kidney involvement, potentially guiding risk stratification and intervention. Addressing pediatric obesity requires a multidisciplinary approach, incorporating lifestyle modifications, medical management, and early detection of organ damage. The aim of this narrative review is to summarize the pathophysiology of pediatric obesity-related kidney damage, current evidence on ultrasound-based screening, and possible diagnostic techniques. Further research is needed to validate ultrasound as a routine screening tool for obesity-related kidney disease in children.

肥胖症相关肾脏疾病:超声应用综述
儿童肥胖是一个日益严重的全球健康问题,与代谢、心血管和肾脏并发症有关。早期发现和干预对于预防长期发病至关重要。本文综述了儿童肥胖的流行病学、病理生理学和临床意义,重点关注其对肾脏健康的影响。我们讨论非侵入性诊断工具,包括肾脏超声和循证管理策略。儿童肥胖与高血压、胰岛素抵抗和肾功能障碍的早期症状(包括肾脏回声增强和高滤过)有关。超声检查结果可作为肾脏受累的早期标志,潜在地指导风险分层和干预。解决儿童肥胖问题需要多学科的方法,包括改变生活方式、医疗管理和早期发现器官损伤。这篇叙述性综述的目的是总结儿童肥胖相关肾损害的病理生理学,目前基于超声筛查的证据,以及可能的诊断技术。需要进一步的研究来验证超声作为儿童肥胖相关肾脏疾病的常规筛查工具。
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来源期刊
CiteScore
6.10
自引率
13.90%
发文量
192
审稿时长
6-12 weeks
期刊介绍: Italian Journal of Pediatrics is an open access peer-reviewed journal that includes all aspects of pediatric medicine. The journal also covers health service and public health research that addresses primary care issues. The journal provides a high-quality forum for pediatricians and other healthcare professionals to report and discuss up-to-the-minute research and expert reviews in the field of pediatric medicine. The journal will continue to develop the range of articles published to enable this invaluable resource to stay at the forefront of the field. Italian Journal of Pediatrics, which commenced in 1975 as Rivista Italiana di Pediatria, provides a high-quality forum for pediatricians and other healthcare professionals to report and discuss up-to-the-minute research and expert reviews in the field of pediatric medicine. The journal will continue to develop the range of articles published to enable this invaluable resource to stay at the forefront of the field.
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