Efficacy and safety of fat graft myringoplasty combined with platelet-rich plasma for managing chronic tympanic membrane perforations: A systemic review and meta-analysis.
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引用次数: 0
Abstract
Objectives: Platelet-rich plasma (PRP) is an autologous product derived from whole blood through the process of gradient density centrifugation. Autologous PRP has been shown to be safe and effective in promoting natural wound healing processes. This study assessed the efficacy of fat graft myringoplasty combined with PRP in tympanic membrane (TM) healing in dry TM perforation due to chronic otitis media and compared it to that of fat graft myringoplasty.
Methods: A systematic review and meta-analysis of prospective or retrospective studies was conducted, with database searches performed through April 2025. The outcomes included the success rate (complete closure of the TM postoperatively) and changes in air-bone conduction gap (ABG) (preoperatively and postoperatively) in the audiogram.
Results: Five studies (n = 522) were included. Fat myringoplasty with PRP resulted in greater improvement in ABGs (SMD 0.3292, 95% confidence interval (CI) [0.1317; 0.5266]) and higher success rates (odds ratio (OR) 3.1289, 95% CI [1.8816; 5.2028]) compared to fat myringoplasty alone. In medium-sized perforations, combination therapy demonstrated superior outcomes in both success rate (success rate (OR 3.1790, 95% CI [1.8914; 5.3432]) and ABG (SMD 0.3569, 95% CI [0.1278; 0.5860]). However, no significant differences were observed in cases involving small perforations (success rate (OR 2.1538, 95% CI [0.1739; 26.6721]) and changes in ABG (SMD 0.2490, 95% CI [-0.1405; 0.6384])). Both liquid and gel PRP significantly improved ABGs and TM closure rates, with no significant difference between types.
Conclusion: This study demonstrated a higher success rate and greater hearing improvement with PRP-assisted fat myringoplasty, especially in medium-sized perforations. Both liquid and gel PRP forms were effective, with no significant difference between them.
期刊介绍:
Clinical and Experimental Otorhinolaryngology (Clin Exp Otorhinolaryngol, CEO) is an international peer-reviewed journal on recent developments in diagnosis and treatment of otorhinolaryngology-head and neck surgery and dedicated to the advancement of patient care in ear, nose, throat, head, and neck disorders. This journal publishes original articles relating to both clinical and basic researches, reviews, and clinical trials, encompassing the whole topics of otorhinolaryngology-head and neck surgery.
CEO was first issued in 2008 and this journal is published in English four times (the last day of February, May, August, and November) per year by the Korean Society of Otorhinolaryngology-Head and Neck Surgery. The Journal aims at publishing evidence-based, scientifically written articles from different disciplines of otorhinolaryngology field.
The readership contains clinical/basic research into current practice in otorhinolaryngology, audiology, speech pathology, head and neck oncology, plastic and reconstructive surgery. The readers are otolaryngologists, head and neck surgeons and oncologists, audiologists, and speech pathologists.