The impact of lifetime excessive alcohol use on behavioural and psychological symptoms of dementia.

IF 2.2 4区 医学 Q3 SUBSTANCE ABUSE
Emytis Tavakoli, Elaina Niciforos, Parmida Amid, Ari B Cuperfain, Amer M Burhan, Sarah Colman, Li Chu, Simon J C Davies, Peter Derkach, Philip Gerretsen, Ariel Graff-Guerrero, Maria Hussain, Zahinoor Ismail, Donna Kim, Linda Krisman, Benoit H Mulsant, Bruce G Pollock, Soham Rej, Aviva Rostas, Tarek K Rajji, Lisa Van Bussel, Sanjeev Kumar, Sarah Elmi
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Abstract

Introduction: Excessive alcohol use (EAU) elevates the risk of dementia through various mechanisms, yet its impact on the behavioural and psychological symptoms of dementia (BPSDs) remains uncertain.

Methods: In this exploratory cross-sectional analysis of baseline data from the Standardizing Care for Neuropsychiatric Symptoms and Quality of Life in Dementia (StaN) study (ClinicalTrials.gov/NCT03672201), we included individuals with Alzheimer's disease and related dementias requiring BPSD treatment. We compared demographic characteristics and presentation of BPSDs (using the total and domain scores on the Neuropsychiatric Inventory-Clinician) in those with and without a lifetime history of EAU.

Results: Among 193 participants [mean (SD) age: 80.6 (9.7) years, male: 48.4%], those in the EAU group (n = 17) and in the comparator group (n = 176) had severe and comparable cognitive impairment, with a median Functional Assessment Staging Tool for Dementia score of 6e. Participants with EAU were significantly younger than comparators [mean age (SD): 72.9 (7.1) years vs. 81.4 (9.5) years] (t = -3.678, df = 181, P < .001), and were more frequently male (76.5% [13 of 17] vs. 46.6% [82 of 176]; P = .036). In a sensitivity analysis, there were no differences in the Neuropsychiatric Inventory-Clinician total or individual domain scores between those with EAU and a subsample of those without EAU matched for age, sex, and recruitment site.

Conclusion: This exploratory study found that among individuals with Alzheimer's disease and related dementias and BPSDs, lifetime history of EAU is more frequent in younger males. Future studies may further examine the impact of EAU in individuals with BPSDs.

终生过度饮酒对痴呆行为和心理症状的影响。
过量饮酒(EAU)通过多种机制提高痴呆的风险,但其对痴呆(bpsd)行为和心理症状的影响仍不确定。方法:在对痴呆患者神经精神症状和生活质量标准化护理(StaN)研究(ClinicalTrials.gov/NCT03672201)基线数据的探索性横断面分析中,我们纳入了需要BPSD治疗的阿尔茨海默病和相关痴呆患者。我们比较了有和没有EAU病史的bpsd的人口学特征和表现(使用临床神经精神病学量表的总分和领域分数)。结果:在193名参与者中[平均(SD)年龄:80.6(9.7)岁,男性:48.4%],EAU组(n = 17)和比较组(n = 176)有严重和可比较的认知障碍,痴呆功能评估分期工具评分中位数为6e。EAU患者明显比对照组年轻[平均年龄(SD): 72.9(7.1)岁vs. 81.4(9.5)岁](t = -3.678, df = 181, P)结论:本探索性研究发现,在阿尔茨海默病及相关痴呆和bpsd患者中,EAU终生史在年轻男性中更为常见。未来的研究可能会进一步研究EAU对bpsd患者的影响。
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来源期刊
Alcohol and alcoholism
Alcohol and alcoholism 医学-药物滥用
CiteScore
4.70
自引率
3.60%
发文量
62
审稿时长
4-8 weeks
期刊介绍: About the Journal Alcohol and Alcoholism publishes papers on the biomedical, psychological, and sociological aspects of alcoholism and alcohol research, provided that they make a new and significant contribution to knowledge in the field. Papers include new results obtained experimentally, descriptions of new experimental (including clinical) methods of importance to the field of alcohol research and treatment, or new interpretations of existing results. Theoretical contributions are considered equally with papers dealing with experimental work provided that such theoretical contributions are not of a largely speculative or philosophical nature.
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