Microbiome-Mediated Modulation of the Tumour Immune Microenvironment in Oesophageal Squamous Cell Carcinoma

IF 2.6 3区 生物学 Q3 MATERIALS SCIENCE, BIOMATERIALS
Lijing Bai, Anchao Zhu
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Abstract

Oesophageal squamous cell carcinoma (ESCC) is the most prevalent type of oesophageal cancer. It is an aggressive malignancy with a poor prognosis, and recent studies have revealed the critical role of the microbiota in its occurrence and development. In this review, the current understanding of the impact of microbiota is summarized on the tumour immune microenvironment (TIME) in ESCC, focusing on intratumoural microbes and the oral-gut microbiota axis as potential therapeutic targets. The mechanisms are discussed by which specific bacterial species, such as Fusobacterium nucleatum (F. nucleatum), Porphyromonas gingivalis (P. gingivalis), Streptococcus spp., and Lactobacillus spp., influence immune responses and contribute to the progression of ESCC. Additionally, the potential of the microbiota is highlighted as a biomarker for early detection, prognosis, and prediction of treatment responses, and explore emerging strategies in microbiota-based immunotherapy that exploit the tumour-targeting properties of bacteria to improve cancer treatment outcomes. Despite these promising developments, the complex interactions between the microbiota and the immune system remain unclarified, and translating research findings into clinical practice is a significant challenge. In this review, the current advancements and emphasise the need for further investigation is summarized into the mechanisms of microbiota-mediated immunotherapy, while outlining future directions for developing personalised treatments for ESCC

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微生物介导的食管癌肿瘤免疫微环境的调节。
食管鳞状细胞癌(ESCC)是最常见的食管癌类型。它是一种预后不良的侵袭性恶性肿瘤,最近的研究揭示了微生物群在其发生和发展中的关键作用。本文综述了微生物群对ESCC肿瘤免疫微环境(TIME)的影响,重点介绍了肿瘤内微生物和口腔肠道微生物群轴作为潜在的治疗靶点。本文讨论了特定细菌种类,如核梭菌(F. nucleatum)、牙龈卟啉单胞菌(P. gingivalis)、链球菌和乳酸杆菌等影响免疫反应并促进ESCC进展的机制。此外,微生物群的潜力被强调为早期检测、预后和预测治疗反应的生物标志物,并探索基于微生物群的免疫治疗的新兴策略,利用细菌的肿瘤靶向特性来改善癌症治疗结果。尽管有这些有希望的发展,但微生物群和免疫系统之间复杂的相互作用仍然不清楚,将研究结果转化为临床实践是一个重大挑战。本文综述了微生物介导的免疫治疗机制的研究进展,并指出了ESCC个性化治疗的未来发展方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Advanced biology
Advanced biology Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
6.60
自引率
0.00%
发文量
130
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