Lifestyle Composite and Resilience to Alzheimer's Disease Pathology in Down Syndrome

IF 1.9 3区医学 Q2 PSYCHOLOGY, EDUCATIONAL

Journal of Applied Research in Intellectual Disabilities Pub Date : 2025-08-13 DOI:10.1111/jar.70109

Emily K. Schworer, Matthew D. Zammit, Benjamin L. Handen, Brianna Piro-Gambetti, Melissa R. Jenkins, Courtney Brothers, Ozioma C. Okonkwo, Christy L. Hom, Beau M. Ances, Bradley T. Christian, Sigan L. Hartley

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Abstract

Background

People with Down syndrome (DS) have a high risk for Alzheimer's disease (AD). Identifying resiliency factors for AD is of critical importance to the DS community.

Method

Participants were 63 adults with DS. Measures included amyloid-beta PET scans (amyloid age), National Task Group-Early Detection Screen for Dementia (NTG-EDSD), and Down Syndrome Mental Status Examination (DSMSE). Lifestyle composites were created by assessing time spent in leisure, employment, and physical activity across 7 days through informant reports and accelerometry.

Results

There was a significant moderation effect of the lifestyle composite on the association between amyloid age and the NTG-EDSD and DSMSE. Participants with a higher lifestyle composite (higher leisure, employment engagement, and physical activity) had fewer dementia symptoms than those with a lower lifestyle composite score of a similar amyloid age.

Conclusions

Modifiable lifestyle factors may allow adults with DS to maintain cognitive functioning for longer in the face of AD pathology.

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唐氏综合征患者生活方式复合与对阿尔茨海默病病理的恢复力

唐氏综合症（DS）患者患阿尔茨海默病（AD）的风险很高。确定AD的弹性因素对DS社区至关重要。方法63例成人退行性痴呆患者。测量方法包括淀粉样蛋白- β PET扫描（淀粉样蛋白年龄），国家任务组痴呆症早期检测筛查（NTG-EDSD）和唐氏综合症精神状态检查（DSMSE）。通过信息报告和加速度计，通过评估7天内休闲、就业和体育活动的时间来创建生活方式复合材料。结果生活方式组合对淀粉样蛋白年龄与NTG-EDSD和DSMSE的相关性有显著调节作用。与淀粉样蛋白年龄相近的生活方式综合评分较低的参与者相比，生活方式综合评分较高的参与者（闲暇时间、工作投入和体育活动较多）痴呆症状较少。结论：可改变的生活方式因素可能使成人退行性痴呆患者在面对AD病理时保持更长时间的认知功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Applied Research in Intellectual Disabilities Multiple-

CiteScore

4.70

自引率

12.50%

发文量

期刊介绍： JARID is an international, peer-reviewed journal which draws together findings derived from original applied research in intellectual disabilities. The journal is an important forum for the dissemination of ideas to promote valued lifestyles for people with intellectual disabilities. It reports on research from the UK and overseas by authors from all relevant professional disciplines. It is aimed at an international, multi-disciplinary readership. Topics covered include community living, quality of life, challenging behaviour, communication, sexuality, medication, ageing, supported employment, family issues, mental health, physical health, autism, economic issues, social networks, staff stress, staff training, epidemiology and service provision.