Meijuan Lin, Li Wei, Yubing Zhou, Huanfeng Jiang, Chaorong Qi
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引用次数: 0
Abstract
A nickel-catalyzed carbonylative cross-electrophile coupling of aryl iodides and alkyl bromides has been successfully developed with carbon dioxide as a carbon monoxide surrogate via a one-pot, two-step procedure. The reaction provides an efficient and complementary method for the synthesis of a wide range of valuable aryl alkyl ketones under mild reaction conditions. Simple operation, high functional group tolerance, and wide substrate scope are also features of the protocol. Moreover, the method can be used for late-stage modification of bioactive complex molecules. Preliminary investigation of the mechanism of the reductive cross-electrophile carbonylation reaction showed that the reaction proceeds through a radical pathway.
期刊介绍：
Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC)
The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
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