Arben Beriša, Filip Duplić, Marko Purić, Matija Gredičak, Nikola Topolovčan
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Abstract
In this study, we describe the operationally simple construction of a tetrasubstituted carbon center utilizing in situ formation of 3-methyleneisoindolinones as reactive intermediates. An acid-catalyzed Meyer–Schuster rearrangement of isoindolinone-based propargylic alcohols followed by an intermolecular Friedel–Crafts alkylation assembles the 3,3-disubstituted isoindolinones, an important architectural motif found in numerous biologically active compounds. Highly inert to structural changes in building blocks, this robust transformation allows the quick build-up of a library of compounds with an embedded isoindolinone core. In addition, the in situ formation of the activated intermediate allows a selective installation of various structural characteristics
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期刊介绍：
Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC)
The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
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