Candida kefyr as an emerging cause of invasive fungal infection in transplant patients: Case report and literature review

IF 1.8 4区医学 Q3 INFECTIOUS DISEASES

Diagnostic microbiology and infectious disease Pub Date : 2025-08-05 DOI:10.1016/j.diagmicrobio.2025.117052

Yasemin Nadir

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引用次数: 0

Abstract

Background

Kluyveromyces marxianus, formerly known as Candida kefyr, is an emerging opportunistic yeast increasingly reported in immunocompromised hosts. This review aims to summarize the clinical presentations, diagnostic approaches, treatment strategies, and outcomes of C. kefyr infections among transplantation recipients through an analysis of published case reports. A comprehensive literature search was performed using PubMed, Scopus, and Web of Science for case reports involving transplantation patients infected with C. kefyr. The review included only individual case reports describing invasive fungal infections in solid organ or hematopoietic stem cell transplant recipients. A total of seven case reports were identified. Clinical presentations included fungemia, keratitis and catheter-related bloodstream infections. Median age was 61.0. Most of the case had neutropenia and consumption of dairy products. Also, the ratio of localized organ involvement is higher. C. kefyr should be considered a potential opportunistic pathogen in transplant recipients, particularly in older or neutropenic patients with regular dairy consumption. Early diagnosis and appropriate antifungal therapy are essential for favorable outcomes.

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假丝酵母菌是移植患者侵袭性真菌感染的新原因：病例报告和文献复习

马氏kluyveromyces marxianus，以前称为念珠菌kefyr，是一种新兴的机会性酵母，越来越多地报道在免疫功能低下的宿主中。本综述旨在通过对已发表病例报告的分析，总结移植受者中C. kefyr感染的临床表现、诊断方法、治疗策略和结果。我们使用PubMed、Scopus和Web of Science对涉及移植患者感染C. kefyr的病例报告进行了全面的文献检索。该综述仅包括实体器官或造血干细胞移植受者侵袭性真菌感染的个案报告。共发现了7例病例报告。临床表现包括真菌血症、角膜炎和导管相关血流感染。中位年龄为61.0岁。大多数病例患有中性粒细胞减少症和食用乳制品。此外，局部器官受累的比例更高。在移植受者中，特别是在老年人或经常食用乳制品的中性粒细胞减少患者中，应将C. kefyr视为潜在的机会性病原体。早期诊断和适当的抗真菌治疗是获得良好结果的必要条件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.