Epstein-Barr virus (EBV) infection and its sequelae in the immunocompetent host

IF 3.4 3区医学 Q2 VIROLOGY

Journal of Clinical Virology Pub Date : 2025-08-08 DOI:10.1016/j.jcv.2025.105854

Madeline R. Meirhaeghe , Henry H. Balfour Jr.

引用次数: 0

Abstract

Epstein-Barr virus (EBV) is best known as the cause of infectious mononucleosis, which is the most common clinical manifestation of primary EBV infection. Infectious mononucleosis is not a trivial disease, but its importance is overshadowed by the disease burden due to the sequelae of primary EBV infection. This review focuses on the sequelae of EBV infection in the immunocompetent host. These include cancers of lymphoid and epithelial cells, and autoimmune diseases, especially multiple sclerosis (MS).

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eb病毒（EBV）感染及其在免疫活性宿主中的后遗症

eb病毒（EBV）被认为是感染性单核细胞增多症的病因，这是原发性EBV感染最常见的临床表现。传染性单核细胞增多症不是一种微不足道的疾病，但它的重要性被由于原发性EBV感染的后遗症所造成的疾病负担所掩盖。本文综述了EBV感染在免疫功能强的宿主中的后遗症。这些包括淋巴细胞癌和上皮细胞癌，以及自身免疫性疾病，尤其是多发性硬化症（MS）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Virology 医学-病毒学

CiteScore

22.70

自引率

1.10%

发文量

149

审稿时长

24 days

期刊介绍： The Journal of Clinical Virology, an esteemed international publication, serves as the official journal for both the Pan American Society for Clinical Virology and The European Society for Clinical Virology. Dedicated to advancing the understanding of human virology in clinical settings, the Journal of Clinical Virology focuses on disseminating research papers and reviews pertaining to the clinical aspects of virology. Its scope encompasses articles discussing diagnostic methodologies and virus-induced clinical conditions, with an emphasis on practicality and relevance to clinical practice. The journal publishes on topics that include: • new diagnostic technologies • nucleic acid amplification and serologic testing • targeted and metagenomic next-generation sequencing • emerging pandemic viral threats • respiratory viruses • transplant viruses • chronic viral infections • cancer-associated viruses • gastrointestinal viruses • central nervous system viruses • one health (excludes animal health)