Time from waking to first cigarette, accelerated biological aging, and risk of premature mortality

IF 3.6 2区医学 Q1 PSYCHIATRY

Drug and alcohol dependence Pub Date : 2025-08-07 DOI:10.1016/j.drugalcdep.2025.112825

Haoxiang Liu , Bingxin Shang , Yuxin Yao , Shiyu Yang , Xin Fan , Xin Lin , Yujia Xie , Haoyu Yin , Xiaojie You , Fuye Li , Jixuan Ma

{"title":"Time from waking to first cigarette, accelerated biological aging, and risk of premature mortality","authors":"Haoxiang Liu , Bingxin Shang , Yuxin Yao , Shiyu Yang , Xin Fan , Xin Lin , Yujia Xie , Haoyu Yin , Xiaojie You , Fuye Li , Jixuan Ma","doi":"10.1016/j.drugalcdep.2025.112825","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>The relationship between the time from waking to first cigarette (TWFC) and premature mortality remains unclear. This study aims to assess the association between TWFC and the risk of premature mortality, and to explore the role of accelerated biological aging in this relationship.</div></div><div><h3>Methods</h3><div>A total of 309,308 participants from the UK Biobank were included in this study. We used the Klemera-Doubal method biological age (KDM-BA) and the phenotypic age (PhenoAge) algorithms to assess accelerated biological aging. The Cox proportional hazards regression model was performed to calculate the hazard ratio (HR) and 95 % confidence interval (CI) of premature mortality with TWFC.</div></div><div><h3>Results</h3><div>During a median follow-up of 12.85 years, 14,725 premature deaths were identified. We observed that the shorter TWFC was associated with a higher risk of premature mortality (<em>P</em> trend < 0.001). Compared with subjects who never smoked, the adjusted HR (95 % CI) of premature mortality was 2.54 (2.28, 2.84) among subjects with TWFC < 5min. Similarly, participants whose TWFC < 5min had 8.955 (95 % CI, 8.951–8.958) months less time to premature death than those who never smoked at 12 years of follow-up. Moreover, accelerated biological aging partially mediated 10.35 %-24.57 % of the relationships between TWFC and risk of premature mortality.</div></div><div><h3>Conclusions</h3><div>A shorter TWFC is associated with an increased risk of premature mortality, and the association may be mediated by accelerated biological aging.</div></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"275 ","pages":"Article 112825"},"PeriodicalIF":3.6000,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug and alcohol dependence","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0376871625002789","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

The relationship between the time from waking to first cigarette (TWFC) and premature mortality remains unclear. This study aims to assess the association between TWFC and the risk of premature mortality, and to explore the role of accelerated biological aging in this relationship.

Methods

A total of 309,308 participants from the UK Biobank were included in this study. We used the Klemera-Doubal method biological age (KDM-BA) and the phenotypic age (PhenoAge) algorithms to assess accelerated biological aging. The Cox proportional hazards regression model was performed to calculate the hazard ratio (HR) and 95 % confidence interval (CI) of premature mortality with TWFC.

Results

During a median follow-up of 12.85 years, 14,725 premature deaths were identified. We observed that the shorter TWFC was associated with a higher risk of premature mortality (P trend < 0.001). Compared with subjects who never smoked, the adjusted HR (95 % CI) of premature mortality was 2.54 (2.28, 2.84) among subjects with TWFC < 5 min. Similarly, participants whose TWFC < 5 min had 8.955 (95 % CI, 8.951–8.958) months less time to premature death than those who never smoked at 12 years of follow-up. Moreover, accelerated biological aging partially mediated 10.35 %-24.57 % of the relationships between TWFC and risk of premature mortality.

Conclusions

A shorter TWFC is associated with an increased risk of premature mortality, and the association may be mediated by accelerated biological aging.

查看原文本刊更多论文

从醒来到抽第一支烟的时间，加速的生物老化和过早死亡的风险

从醒来到吸第一支烟的时间（TWFC）与过早死亡率之间的关系尚不清楚。本研究旨在评估TWFC与过早死亡风险之间的关系，并探讨加速生物衰老在这一关系中的作用。方法本研究共纳入来自英国生物样本库的309308名受试者。我们使用klemera - double方法生物年龄（KDM-BA）和表型年龄（PhenoAge）算法来评估加速的生物衰老。采用Cox比例风险回归模型计算TWFC导致过早死亡的风险比（HR）和95%可信区间（CI）。结果在中位随访12.85年期间，发现14725例过早死亡。我们观察到，较短的TWFC与较高的过早死亡风险相关(P趋势<；0.001)。与从不吸烟的受试者相比，TWFC <； 5分钟的受试者过早死亡的调整HR （95% CI）为2.54（2.28,2.84）。同样，在12年的随访中，TWFC <； 5分钟的受试者比从不吸烟的受试者早死的时间少8.955 （95% CI, 8.951-8.958）个月。此外，加速的生物老化部分介导了10.35% - 24.57%的TWFC与过早死亡风险之间的关系。结论TWFC变短与过早死亡风险增加有关，其机制可能与生物衰老加速有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Drug and alcohol dependence 医学-精神病学

CiteScore

7.40

自引率

7.10%

发文量

409

审稿时长

41 days

期刊介绍： Drug and Alcohol Dependence is an international journal devoted to publishing original research, scholarly reviews, commentaries, and policy analyses in the area of drug, alcohol and tobacco use and dependence. Articles range from studies of the chemistry of substances of abuse, their actions at molecular and cellular sites, in vitro and in vivo investigations of their biochemical, pharmacological and behavioural actions, laboratory-based and clinical research in humans, substance abuse treatment and prevention research, and studies employing methods from epidemiology, sociology, and economics.