Young onset colorectal cancer in hereditary syndromes

IF 0.5 Q4 SURGERY

Seminars in Colon and Rectal Surgery Pub Date : 2025-07-22 DOI:10.1016/j.scrs.2025.101121

Thomas A. Sorrentino , B. Mark Zhao

引用次数: 0

Abstract

Colorectal cancer (CRC) is a leading cause of cancer-related deaths globally, with rising concerns about its increased incidence in individuals under 50, termed young-onset CRC. Despite declines in CRC rates overall, young-onset CRC has risen by 1–3 % annually in the US and Europe. This rise is most pronounced in rectal cancer and is projected to result in significant growth in CRC cases among individuals aged 20–49 over the next decade. While most young-onset CRCs are sporadic, approximately 15 % of cases are linked to genetic syndromes. This review explores the genetic syndromes associated with young-onset CRC, distinguishing between polyposis and non-polyposis types, and discusses diagnostic strategies, management, and multidisciplinary care approaches essential for colorectal surgeons treating these patients.

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年轻发病的结直肠癌的遗传综合征

结直肠癌（CRC）是全球癌症相关死亡的主要原因，人们越来越关注其在50岁以下个体中的发病率增加，称为年轻发病的CRC。尽管结直肠癌发病率总体上有所下降，但在美国和欧洲，年轻发病的结直肠癌发病率每年上升1 - 3%。这种上升在直肠癌中最为明显，预计在未来十年中，20-49岁人群中结直肠癌病例将显著增加。虽然大多数年轻发病的crc是散发的，但大约15%的病例与遗传综合征有关。这篇综述探讨了与年轻发病的CRC相关的遗传综合征，区分息肉病和非息肉病类型，并讨论了治疗这些患者的诊断策略、管理和多学科治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Colon and Rectal Surgery SURGERY-

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： Seminars in Colon and Rectal Surgery offers a comprehensive and coordinated review of a single, timely topic related to the diagnosis and treatment of proctologic diseases. Each issue is an organized compendium of practical information that serves as a lasting reference for colorectal surgeons, general surgeons, surgeons in training and their colleagues in medicine with an interest in colorectal disorders.