Cyclization of aminoacetaldehyde dimethyl acetal with α-oxodithioesters in acidic media: an easy way to access 2-acylthiazoles

Abstract

In this letter, we disclose the formation of 2-acylthiazoles by the cyclocondensation of aminoacetaldehyde dimethyl acetal with α-oxodithioesters in the presence of p-tolunesulfonic acid in DMF at 80 °C. The present method reduces a step for the synthesis of 2-acylthiazoles from α-oxodithioesters and thus overcome the limitation of our earlier work which involves the reaction between α-oxothioamides and bromoacetaldehyde diethyl acetal. The generality of the reaction has been demonstrated in the presence of various electro neutral, electron donating and electron withdrawing groups. High overall yields and relatively shorter reaction times for some reactions are the prons of this protocol.