Surgical Antibiotic Prophylaxis Used in A University Clinics Hospital and Antibiotic Costs: A 3-year Survey

IF 1.5 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Current Therapeutic Research-clinical and Experimental Pub Date : 2025-01-01 DOI:10.1016/j.curtheres.2025.100807

Vianney N. Ntabaza PhD , Antonelle Pardo PhD , Amandine Nachtergael PhD , Julien Bamps MSc , Salvius A. Bakari PhD , Pierre Duez PhD , Stephanie Patris PhD , Byanga Kahumba PhD

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引用次数: 0

Abstract

Background

Surgical Site Infections (SSIs) represent one of the most common post-operative complications and are the third most prevalent nosocomial infections.

Objective

The objective of this study was to analyze the conditions of using antibiotics in surgery at the University Clinics of Lubumbashi.

Methods

A retrospective study was conducted, collecting data from medical registers over a 3-year period, from 2017 to 2019. Parameters have been analyzed according to the European Centre for Disease Prevention and Control (ECDC), National Institute for Health and Care Excellence (NICE) and World Health Organization (WHO) guidelines.

Results

Shortcomings in registered data and the application of exclusion criteria allowed to include only 256 of the 977 retrospective procedures recorded during this period, with around 50% of the cases in 2019. A little more than half of them concerned men with a sex ratio of 1.28. Among these patients, 66% were aged between 16 and 40 years. Of these, 37.1% underwent visceral surgery. Over 38.7% of patients were hospitalized for more than 30 days, with 4.3% staying over 4 months. After the surgery, metronidazole 1.5 g, ceftriaxone 1 g and cefotaxime 1 g were the most used (89%) antibiotics followed by amoxicillin 1 g, all mainly parenterally. In 38,7% of cases, a series of other antibiotics were used in combination over a long period (7 days). A 32.8% rate of surgical site infection was recorded, with antibiotic-related costs of around 62,311 ± 30,417 CDF (31 ± 15 €). A comparison of the characteristics of patients with and without infections showed a significant influence of the sex and type of surgery. Men were 4.7 times more likely to develop a surgical site infection than women, and orthopedic surgery had a higher risk of infection than other surgeries.

Conclusion

These retrospective data suggest that the use of antibiotics before and after surgery at the University Clinics of Lubumbashi does not meet accepted standards (ECDC, NICE and WHO guidelines) and would not be efficient for their intended purpose.

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某大学医院外科抗生素预防使用与抗生素费用：一项为期3年的调查

背景手术部位感染（ssi）是最常见的术后并发症之一，也是第三大常见的医院感染。目的分析卢本巴希大学诊所外科手术中抗生素的使用情况。方法采用回顾性研究方法，收集2017 - 2019年3年间的医疗登记数据。根据欧洲疾病预防和控制中心（ECDC）、国家健康和护理卓越研究所（NICE）和世界卫生组织（世卫组织）的指导方针分析了参数。结果：在此期间记录的977例回顾性手术中，登记数据的缺陷和排除标准的应用仅允许纳入256例，其中约50%的病例发生在2019年。其中一半多一点是男性，男女性别比为1.28。在这些患者中，66%的年龄在16至40岁之间。其中，37.1%的患者接受了内脏手术。超过38.7%的患者住院时间超过30天，4.3%的患者住院时间超过4个月。术后使用甲硝唑1.5 g、头孢曲松1 g、头孢噻肟1 g最多（89%），其次是阿莫西林1 g，均以肠外注射为主。在38.7%的病例中，长期（7天）联合使用一系列其他抗生素。手术部位感染率为32.8%，抗生素相关费用约为62,311±30,417 CDF（31±15€）。对感染和未感染患者的特征进行比较，发现性别和手术类型对其有显著影响。男性发生手术部位感染的可能性是女性的4.7倍，而骨科手术的感染风险高于其他手术。这些回顾性数据表明，卢本巴希大学诊所手术前后抗生素的使用不符合公认的标准（ECDC、NICE和WHO指南），无法达到预期目的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Therapeutic Research-clinical and Experimental 医学-药学

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

3 months

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