Evolving Landscape: Accounts of Academic-Industrial Collaborations in Chemistry Technology

IF 4 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2025-07-28 DOI:10.1021/acsmedchemlett.5c00373

Aristidis Vasilopoulos*, and , Ying Wang*,

引用次数: 0

Abstract

Academic-industrial collaborations in the pharmaceutical industry have led to advances in novel science and pipeline goals. These partnerships find success by leveraging the resources and expertise of the industrial sector with the creativity and depth of knowledge of academic researchers. Here, we discuss case studies of several past and present academic-industrial collaborations from a chemistry technology group and their evolution from operating under funding-driven models to more reciprocal exchanges of effort and information. Effective partnerships depend on the careful selection of the right collaborators and projects, and they require clear communication, alignment of interests, and patience throughout the phases of a collaboration. Research areas of high interest for academic collaborations are discussed, such as advancements in synthetic methodology and drug discovery platforms such as DNA-encoded libraries and PROTACS.

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不断发展的景观：化学技术的学术-工业合作

制药行业的学术-工业合作导致了新科学和管道目标的进步。通过利用工业部门的资源和专业知识以及学术研究人员的创造力和知识深度，这些伙伴关系取得了成功。在这里，我们将讨论一个化学技术集团过去和现在的几个学术-工业合作的案例研究，以及它们从在资金驱动模式下运作到更互惠的努力和信息交流的演变。有效的伙伴关系依赖于仔细选择合适的合作者和项目，它们需要在合作的各个阶段进行清晰的沟通、利益一致和耐心。讨论了学术合作的高兴趣研究领域，如合成方法的进展和药物发现平台，如dna编码文库和PROTACS。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.