Cross-species analysis of adult hippocampal neurogenesis reveals human-specific features

IF 20 1区医学 Q1 NEUROSCIENCES

Nature neuroscience Pub Date : 2025-08-12 DOI:10.1038/s41593-025-02029-7

引用次数: 0

Abstract

Human-specialized features of immature dentate granule cells (imGCs) formed during adult hippocampal neurogenesis are poorly characterized. Using machine learning-augmented analysis of single-cell RNA-sequencing data, we have revealed human-specific gene expression but convergent biological processes for imGCs across mammalian species. We further demonstrated functional roles of human imGC-enriched proton-transporting ATPase subtypes in neuronal development.

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成人海马神经发生的跨物种分析揭示了人类特有的特征

成人海马神经发生过程中形成的未成熟齿状颗粒细胞（imGCs）的人类特化特征尚不清楚。利用单细胞rna测序数据的机器学习增强分析，我们揭示了哺乳动物物种中imGCs的人类特异性基因表达和趋同的生物学过程。我们进一步证明了人类富含imgc的质子转运ATPase亚型在神经元发育中的功能作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature neuroscience 医学-神经科学

CiteScore

38.60

自引率

1.20%

发文量

212

审稿时长

1 months

期刊介绍： Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.